What is Pueraria root kudzu root?Value of Pueraria root kudzu root and Pueraria root kudzu root extracts?

Contents

• Pueraria root:Pueraria root kudzu root extracts,Puerarin
• Traditional Chinese Medicine Description.
• Pueraria root Chemical Composition.
• Pharmacology.
• Pharmacokinetics.
• Toxicity and Safety.
• Clinical Studies.
• Kudzu Root Modern Researches.
• How Search engine think about kudzu.
• Research update of Pueraria root.
• Photo Gallery of Pueraria lobata.

Kudzu Root Modern Researches.:

This herb mainly contains flavones, such as daidzein, daidzin, daidzein-4, 7-diglucose glucoside, puerarin, puerarin-7-xyloside, puerarol, xylopuerarin, isoflavonoid glycoside and starch. Kudzu vine root can dilate coronary vessels and cerebral blood vessels and increase the blood flow of coronary arteries.

 Total flavone of kudzu vine root can reduce the myocardial oxygen consumption and increase the supply of oxygen. Kudzu vine root can directly dilate the blood vessels to lower peripheral resistance. It can also reduce blood pressure remarkably and alleviate the "nape tension" symptom of a patient with a high blood pressure in a better way. Puerarin can inhibit the platelet aggregation. Kudzu vine root has an extensive blocking effect on beta-receptors. Kudzu vine root also has an obvious antipyretic effect and can also reduce blood sugar slightly.

 Updates:

 1.Determination of 12 pueraria components by high-performance liquid chromatography-mass spectrometry:

 Puerariae radix, a commonly used Chinese herb drug derived from the dried root of legume plant, contains a series of isoflavones as its chief pharmacologically active constituents. Using 12 pueraria components as markers, an LC-UV-MS method requiring less than 60 min, was developed for estimating the quality of pueraria samples within 60 min. Extracts were analyzed using a Cosmosil 5C18-MS column, by gradient elution with an aqueous solution of acetic acid and methanol-ACN at a flow-rate of 1.0 mL/min. Peaks were detected at 254 nm and each peak was identified by LC/MS. The reproducibilities (RSD) of this proposed method, on the basis of peak-area ratios from six replicate injections, were 0.93-1.42% (intraday) and 1.05-1.63% (interday) at a detection limit of 0.12-0.78 microg/mL. Most of the markers used in this study can be classified, respectively, into three major categories, namely, isoflavones, O-glycosidic isoflavones, and C-glycosidic isoflavones. The structures of the compounds were determined from LC-MS fragmentation data and data from the literature.
 


 2.An extract of the Chinese herbal root kudzu reduces alcohol drinking by heavy drinkers in a naturalistic setting:

 Background: Of the available medications for treating alcohol-related problems, none are universally effective, and all have side effects that may limit their use. Extracts of kudzu containing a variety of isoflavones have been shown to reduce alcohol drinking in rats and hamsters.
 Methods:The present study was designed to test the efficacy of a kudzu extract in a clinical population. Male and female "heavy" alcohol drinkers were treated with either placebo or a kudzu extract for 7 days and then given an opportunity to drink their preferred brand of beer while in a naturalistic laboratory setting. Participants served as their own controls, and order of treatment exposure was counterbalanced. Drinking behavior was monitored by a digital scale that was located in the top of an end table.
 Results:Kudzu treatment resulted in significant reduction in the number of beers consumed that was paralleled by an increase in the number of sips and the time to consume each beer and a decrease in the volume of each sip. These changes occurred in the absence of a significant effect on the urge to drink alcohol. There were no reported side effects of kudzu treatment.
 Conclusion: These data suggest that an extract of this leguminous plant may be a useful adjunct in reducing alcohol intake in a naturalistic setting.

 3.Combination Case Study:Breast Pretty Precious

 There are many combination with pueraria root aim at breast beauty with other herbs, a product named Breast Pretty Precious exampled as given below:Combined with herbs pawpaw fruit,Pueraria root,Wild Yam,Logan,Chinese Date,Wolfberry fruit,Tomato,Semen Coicis,Grapeseed,Soy milk,Vitamin B6,Vitamin B12,Vitamin E,etc and lactose as additives.
 Suggest taken 5grams twice daily, before breakfast and night dreams. It is said to make girl breast enlarged from D to G size.


 4.Antitumor activity of spinasterol isolated from Pueraria roots.:

 We purified phytoestrogens from Pueraria root (Pueraria mirifica from Thailand and Pueraria lobata from Korea), which is used as a rejuvenating folk medicine in Thailand and China. Dried, powdered plant material was extracted with 100% ethanol and further separated by concentration, filtration, and thin layer silica gel chromatography. Using the fractions obtained during separation, we first investigated their cytotoxicity in several cancer cell lines from various tissues. The ethanol-extracted components (PE1, PE4) had significant antiproliferative effects on breast cancer cell lines, including MCF-7, ZR-75-1, MDA-MB-231, SK-BR-3, and Hs578T. Second, we compared these results with the cytotoxic effects of known flavonoids, sterols, and coumarins from Pueraria root. The known compounds were not as effective, and occurred in a different polarity region on HPLC. Third, further separation resulted in the isolation of eight different components (Sub PE-A to -H). One of these, PE-D, affected the growth of some breast cancer cell lines (MCF-7, MDA- MB-231) in a dose- and time-dependent manner, as well as the growth of ovarian (2774) and cervical cancer cells (HeLa). Finally, a transfection assay showed that this component had an estrogenic effect similar to 17beta - estradiol, which activates both estrogen receptor alpha (ERalpha) and ERbeta. The NMR analysis determined that spinasterol (stigmasta-7, 22-dien-3beta-ol) is an active cytotoxic component of Pueraria root.


 5.Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography.:

 The estrogenic activity of the Chinese herb kudzu root was investigated by a recombinant yeast screening assay (YES). Isoflavones are the main components in the plant, of which puerarin is the most abundant one. The kudzu root extract was separated into four fractions according to the polarity. The crude extract and its sub-fractions, except the water fraction, showed clear estrogenic activity and the potencies were in the range of 10(-3) to 10(-1)g/l. The ligand potency was used to compare the estrogenic activity of these fractions. The crude extract and its sub-fractions were further analyzed by high performance liquid chromatography (HPLC) to correlate the activity and the active components. Bioassay and chemical analysis showed that theoretical estrogenic activity expressed as equivalent 17beta-estradiol concentration or the cumulative effects are comparable to that experimentally determined by YES. The results showed that the high content of isoflavones as well as the high estrogenic activity could make kudzu root extract an interesting candidate for hormone replacement therapy.
   

 6.Quantitative analysis of phytoestrogens in kudzu-root, soy and spiked serum samples by high-pressure liquid chromatography.:

 A sensitive and reliable HPLC method that allows simultaneous quantification of phytoestrogens extracted from kudzu-root and soy preparations, and serum samples has been developed. Kudzu-root and soy preparations were mixed with 5 microg flavone and 15 microg rutin (internal standards) and the phytoestrogens were extracted by using solid-phase (C18) extraction cartridges. Blank or spiked serum samples were extracted by using either C18 cartridges or trichloroacetic acid-methanol extraction. The extracts were analyzed by the HPLC equipped with a reverse-phase (250 x 4 mm, C18) column and UV, diode-array or MS detector. A linear gradient of acetic acid and acetonitrile provided excellent separation of glycoside and aglycone-phytoestrogens from kudzu root and soy preparations. The C18 cartridge extraction of serum yielded excellent recovery of both glycoside- and aglycone-phytoestrogens, while the trichloroacetic acid-methanol extraction yielded excellent recovery of glycoside but poor recovery of aglycone compounds. UV and MS detectors were suitable for phytoestrogen analysis in plant and serum samples, while the diode-array detector was suitable for generating the UV absorbance curve for phytoestrogens.

Reference:

• What is Pueraria root kudzu root?Value of Pueraria root kudzu root and Pueraria root kudzu root extracts?

This article written and edited via herbalist of MDidea Extracts Professional. They run a range of online descriptions about this herb,including general information related and summarized updating discoveries from findings of professional scientisits this field related.Describe style aimed to form a useful detecting literature space where the intertwined threshold and related questions raise out and visualize themselves.

♣ last edit date:08th,Oct.2010.