Magnolia officinalis,Its Bark Magnolia Cortex,Its Fragrance Components and Magnolia Alkaloids,Magnolol,Honokiol.

Contents

• Botanical Description of Magnolia Bark.
• Narrative History and Ancient Register of Magnolia Bark.
• Magnolia Bark and Its Fragrance Components.
• Properties and Indications of Magnolia Bark.
• Common uses and Application of Magnolia Bark Extract.
• Magnolia Bark:Administration and Suggestions.
• How Search engine think about Magnolia.
• Research Update:Magnolia Bark,Magnolol,Honokiol and Constituents.
• Photo Gallery of Magnolia officinalis.

Magnolia Bark:Administration and Suggestions.:

Toxicity and Adverse Effects:

 Acute Toxicity:

 Magnolia Bark Decoction.LD50.Lethal dose,50 percent death.Injection.Mice.6 grams/kg.
 Magnolia Bark Decoction.LD50.Lethal dose,50 percent death.Intraperitoneal Injection.Mice.6.12+-0.038 grams/kg.
 Magnolia Bark Decoction.LD50.Lethal dose,50 percent death.Subcutaneous Injection.Mice.51 grams/kg.
 Magnolia Bark Decoction.LD50.Lethal dose,50 percent death.Mainline.Cat.4.25+-1.5 grams/kg.
 Magnolia Var biloba Rehd et wils Dry Hide before Diaphoretic Processing.LD50.Lethal dose,50 percent death.Intraperitoneal Injection.Mice.24.21+-4.5 grams/kg.
 Magnolia Var biloba Rehd et wils Dry Hide after Diaphoretic Processing.LD50.Lethal dose,50 percent death.Intraperitoneal Injection.Mice.2.67+-0.45 grams/kg.
 Alkaloid magnofluorine.LD50.Lethal dose,50 percent death.Injection.Mice.45 mg/kg.
 Magnolol.LD50.Lethal dose,50 percent death.Injection.Mice.87 mg/kg.
 Honokiol.LD50.Lethal dose,50 percent death.Injection.Mice.98 mg/kg.
 

 Reference:An Experimental Study of The Toxicity of Magnolia Var biloba Rehd et wils Dry Hide before and after its Diaphoretic Processing.Inner Mongolia TCM.2003.02.

 No significant toxicity or adverse effects have been reported to date. In a 1993 article in Lancet, magnolia was mentioned along with stephania (Stephania tetrandra) as suspected ingredients in a complex weight loss regimen that resulted in several cases of renal failure. It was later reported that the herb stephania had come from the source Aristolochia fangchi and suspicion about contribution to the incidence of renal failure was transferred to components of that herb, particularly aristolochic acid, which is not found in magnolia bark. There was no further investigation of magnolia in relation to the problems experienced at that clinic and there is no reason to suspect that it played a role. Laboratory studies of the toxicity of magnolia bark and its components failed to reveal any immediate reason for concern about its use in normal doses: the LD50 of magnolia bark in decoction given by injection was 6 grams per kilogram in mice and the LD50 of the alkaloid magnofluorine was 45 mg/kg by injection in mice. The mean lethal dose of magnolia bark decoction given to cats by intravenous administration was 4.25 g/kg.

 Magnolia is generally regarded as safe when taken in the recommended doses. It should not be used by pregnant women, or for those suffering from dehydration. Safety in young children, nursing women, or those with severe liver or kidney disease is not known.

 Large doses (many times the recommended dosage) may cause vertigo. Magnolia officinalis bark contains turbocurarine and related substances which are known to cause respiratory paralysis in animals and may be toxic to infants and small children, even when used as directed.

 Suggestive Dosage:

 The usual dosage recommendation for magnolia bark in decoction is 3-9 grams. It is also powdered in formulas made in pill form, in which case the daily dose ingested is typically less than 1 gram. Since prolonged boiling of the bark may reduce the content of essential oils and biphenols, the decoction requires a higher dose than the powder that is ingested in pills.

Reference:

• Magnolia officinalis,Its Bark Magnolia Cortex,Its Fragrance Components and Magnolia Alkaloids,Magnolol,Honokiol.

This article written and edited via herbalist of MDidea Extracts Professional. They run a range of online descriptions about this herb,including general information related and summarized updating discoveries from findings of professional scientisits this field related.Describe style aimed to form a useful detecting literature space where the intertwined threshold and related questions raise out and visualize themselves.

♣ last edit date:09th,Oct.2010.