What is Rosmarinic Acid?Super Function of RosA,Rosmarinic Acid?

Contents

• What is Rosmarinic Acid and the botanical origin Purple Perilla?
• Main constituents and Phytochemicals of Purple Perilla.
• Traditional Medicinal Uses of Purple Perilla.
• Rediscovery of Perilla frutescens as medicinal plant and vegetable with health promoting properties.
• Perilla frutescens Extract enriched for polyphenolic phytochemical rosmarinic acid, inhibits seasonal allergic rhinoconjunctivitis in humans.
• Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy.
• Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model.
• Metabolome analysis of anthocyanin-producing Perilla frutescens and an Arabidopsis mutant.
• Common perilla (Perilla frutescens (L.) Britton.) as a perspective immunomodulator.
• Lipoxygenase Inhibitors as Potential Cancer Chemopreventives.
• Perilla leaves Increase the tolerance of the body against pollen.
• Purple Perilla Rosmarinic Acid and its application dosage.
• Medical functions of Rosemarinic Acid.
• Effects of Perilla Seed Extract.
• Application of Perilla leaf.
• Rosemarinic Acid Safety and Toxicology.
• Research update of Perilla related.
• Photo Gallery of Perilla frutescens.

Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model.

Perilla frutescens extract showed marked reduction on tumorigenesis in a murine, two-stage skin carcinogenesis model.

 In this model, cancer is initiated by application of 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by application of 12-tetradecanoylphorbol 13-acetate (TPA). Following tumor initiation with DMBA, topical application of a perilla-derived fraction (PF) at doses of 2 mg/mouse/application resulted in significant inhibition of tumorigenesis.

 The efficacy of each fraction was correlated with rosmarinic acid (RA) and luteolin concentration. Topical application of perilla extract (PE) that contained 68% RA or an equivalent amount of commercially available RA showed nearly identical antiinflammatory activity 5 h after TPA treatment.

 Application of luteolin had less anti-inflammatory activity. Marked neutrophil infiltration was observed in TPA-challenged skin by histological examination using hematoxylin-eosin. This change was greatly reduced by pre-treatment with PE or RA. Myeloperoxidase activity, a marker of neutrophil recruitment, was also increased in TPA-challenged skin and was significantly decreased in the PE and RA treated groups.

 Intercellular adhesion molecule 1 and vascular cell adhesion molecule-1 mRNA expression levels were reduced by pre-treatment with PE or RA. TPA-induced increases in synthesis of the chemokines KC and macrophage inflammatory protein-2 were significantly decreased by pre-treatment with PE or RA. Prostaglandin E2 and leukotriene B4 levels were slightly increased 5 h after TPA treatment.

 These levels were only numerically decreased in the PE and RA treated groups. However, induction of cyclooxygenase-2 mRNA expression was obviously reduced by pre-treatment with PE or RA. Reactive oxygen radical production, detected as thiobarbituric acid reactive substance and lipid peroxide, by double treatment of TPA was reduced by pre-treatment with PE or RA.

 Production of 8-hydroxy-2'deoxyguanosine, which was detected immunohistochemically, was also induced by double treatment with TPA. This adduct was barely visible in PE or RA treated mice.

 Thus, we conclude that part of the anticarcinogenic effects of P.frutescens extract is due to RA via two independent mechanisms: inhibition of the inflammatory response and scavenging of reactive oxygen radicals.

Reference:

• What is Rosmarinic Acid?Super Function of RosA,Rosmarinic Acid?

This article written and edited via herbalist of MDidea Extracts Professional. They run a range of online descriptions about this herb,including general information related and summarized updating discoveries from findings of professional scientisits this field related.Describe style aimed to form a useful detecting literature space where the intertwined threshold and related questions raise out and visualize themselves.

♣ last edit date:08th,Oct.2010.