Milk Thistle:Silybum marianum,its botanical information,constituents,history,applications and administration guide.
- Botanical Information of Silybum marianum.
- Phytochemicals and Constituents of Milk Thistle Seed.
- History of Milk Thistle till recent years.
- Applications and functions of Milk Thistle and its constituents.
- Administration Guide and Safety of Milk Thistle Preparations.
- Pharmacology finding of Milk Thistle.
- The Awesome Power of the Milk Thistle.
- Research Update of Silybum Marianum and its constituents.
- Photo Gallery of Silybum marianum.
Applications and Properties:
Inhibitor of Beta-glucuronidase.
Anti Free radicals.
Hepatoprotective,Liver injury protection of silymarin.
Silymarin reduced lipoperoxidative hepatic damage.
Silymarin proved against hepatotoxicity.
Promotes milk secretion,treat lactation problems,prevent cancer.
A number of studies have suggested that silymarin is an anti-inflammatory. It regulates inflammatory mediators such as tumor necrosis factor (TNF), TNF-alpha, nitrous oxide, interleukin-, and interleukin-1 receptor antagonist. Silymarin also increases lymphocyte proliferation, interferon gamma, interleukin-, and interleukin- cytokines, in a dose-dependent manner. Taken together, these effects suggest a possible role in preventing or treating infectious disease.
Dosage:"For liver dysfunction or ailments,the daily dosage has been effective and well tolerated at 140 to 420mgs divided in 2 to 3 doses(Ferenci,1989;Frerick,1990;Pares,1998;Schuppan,1998).The average dose of silymarin was approximately 33mg/kg/d for cyclopeptide mushroom poisoning.Silymarin administered up to 48 hours after mushroom ingestion appears to be effective in preventing severe liver damage in Amanita phalloides poisoning(Hruby,1983).Although products are usually standardized to 70% to 80%(not milligrams) of silymarin,the silymarin concentrations may vary without government regulation(Flora et al.1998)."
Safety and Toxicity:
Acute toxicity(LD50):Silymarin.LD50-Lethal dose,50 percent kill.Intravenous.Rodent-mouse.>1600 mg/kg.Details of toxic effects not reported other than lethal dose value.
In clinical trials,milk thistle generally has few side effects.Occasionally, people report a laxative effect,upset stomach,diarrhea,and bloating.Milk thistle can produce allergic reactions,which tend to be more common among people who are allergic to plants in the same family (for example,ragweed,chrysanthemum, marigold,and daisy).It is important to inform your health care providers about any herb or dietary supplement you are using,including milk thistle.This helps to ensure safe and coordinated care.
- Milk Thistle:Silybum marianum,its botanical information,constituents,history,applications and administration guide.
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