The Secret of Soy,What is Soy Isoflavones?Function of Natural Genistein?Soy Bean Extract.

Contents

• Basic Info of Soy Isoflavones.
• Introduction and Brief Benefits of Soy Isoflavones.
• Actions and Pharmacology.
• Women's health and Isoflavones.
• Suggestions and Administration.
• Soy Isoflavones Metabolism.
• Soy Isoflavones Estrogenic and Anti-Estrogenic Activities.
• Soy Isoflavones Estrogen Receptor-Independent Activities.
• Soy Isoflavones Prevent Cardiovascular Disease.
• Soy Isoflavones and Hormone-associated Cancers.
• Soy Isoflavones Prevent Osteoporosis.
• Soy Isoflavones Help Prevent Cognitive Decline.
• Soy Isoflavones Treatment Menopausal Symptoms.
• Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans.
• Pharmacokinetics of isoflavones, daidzein and genistein, after ingestion of soy beverage compared with soy extract capsules in postmenopausal Thai women.
• What is genistein?
• Genistein mimics human estrogens.
• Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor Beta.
• Estrogenic Effects of Genistein.
• Effect of genistein to control postmenopausal symptoms and bone loss.
• Safety and Acute toxicity.
• How Search engine think about Genistein.
• Research Update and latest findings of Soy Isoflavones.Daidzein.Daidzin.Genistein.Genistin related.
• Photo Gallery of Glycine max.

Safety and Acute toxicity.:

Genistein:

 Chemical Name: Isoflavone,4',5,7-trihydroxy-
 CAS: 446-72-0.Molecular Formula: C15-H10-O5.Weight: 270.25
 Synonyms: 4H-1-Benzopyran-4-one,5,7-dihydroxy-3-(4-hydroxyphenyl)-;C.I.75610;Differenol A;Genistein;Genisteol;Genisterin;Prunetol;Sophoricol;4',5,7-Trihydroxyisoflavone;5,7,4'-Trihydroxyisoflavone.

 Acute toxicity(LD50):

 LD-Lethal dose,Intraperitoneal.Rodent-mouse.>500mg/kg.
 Details of toxic effects not reported other than lethal dose value.
 Reference: JANTAJ Journal of Antibiotics.V.2-5,1948-52;V.21-1968-Volume(issue)/page/year:39,606,1986.

 Reproductive Data:

 TDLo-Lowest published toxic dose.Subcutaneous.Rodent-rat.125mg/kg.
 Sex/Duration:female 16~20days(s) after conception.
 Toxic Effects: Reproductive-Specific Development Abnormalities-urogenital system.
 Reference: PSEBAA Proceedings of the Society for Experimental Biology and Medicine.(Academic Press, Inc.,1E. First St.Duluth,MN55802)V.1-1903/04-Volume(issue)/page/year:208.60.1995.


 TDLo-Lowest published toxic dose.subcutaneous.Rodent-rat.625mg/kg.
 Sex/Duration:female 16~20 day(s) after conception.
 Toxic Effects: Reproductive-Effects on Newborn-growth statistics(e.g.%,reduced weight gain).
 Reference: PSEBAA Proceedings of the Society for Experimental Biology and Medicine.(Academic Press, Inc.,1E. First St.Duluth,MN55802)V.1-1903/04-Volume(issue)/page/year:208.60.1995.

 TDLo-Lowest published toxic dose.Oral.Rodent-mouse.1680mg/kg.
 Sex/Duration:female 21 day(s) pre-mating.
 Toxic Effects:Reproductive.Maternal Effects.other effects.
 Reference:JOENAK Journal of Endocrinology.(Biochemical Soc.Book Depot,POB32,Commerce Way,Colchester,Essex CO2 8HP,UK)V.1-1939-Volume(issue)/page/year:13.94.1955.

 TDLo-Lowest published toxic dose.Oral.Rodent-mouse.13200mg/kg.
 Sex/Duration:male 22 day(s) pre-mating.
 Toxic Effects: Reproductive-fertility-male fertility index(e.g.#males impregnating females per#males exposed to fertile nonpregnant females).
 Reference:JOENAK Journal of Endocrinology.(Biochemical Soc.Book Depot,POB32,Commerce Way,Colchester,Essex CO2 8HP,UK)V.1-1939-Volume(issue)/page/year:13.94.1955.

 TDLo-Lowest published toxic dose.Oral.Rodent-mouse.18600mg/kg.
 Sex/Duration:male 31 day(s) pre-mating.
 Toxic Effects: Reproductive-Effects on Newborn-stillbirth.
 Reference:JOENAK Journal of Endocrinology.(Biochemical Soc.Book Depot,POB32,Commerce Way,Colchester,Essex CO2 8HP,UK)V.1-1939-Volume(issue)/page/year:13.94.1955.


 Mutagenic Data.

 DNA damage.Test system:Human Cells-not otherwise specified.50mg/L.
 Reference: CNREA8 Cancer Research.(Public Ledger Building,Suit 816,6th Chestnut Sts.,Philadelphia,PA 19106)V.1-1941-Volume(issue)/page/year:50,2618,1990.

 DNA damage.Test system:Human Cells-not otherwise specified.50umol/L.
 Reference: CNCMET Cancer Communications.(Pergamon Press, Inc.,Maxwell House,Fairview Park,Elmsford,New York,10523) V.1-1989-Volume(issue)/page/year:2,271,1990.

 Mutation test systems-not otherwise specified.Test system:Human Cells-not otherwise specified.45 umol/L.
 Reference: CNCMET Cancer Communications.(Pergamon Press, Inc.,Maxwell House,Fairview Park,Elmsford,New York,10523) V.1-1989-Volume(issue)/page/year:2,271,1990.

 Micronucleus test.Test sytem:Rodent-hamster Lung.18 umol/L.
 Reference:FCTOD7 Food and Chemical Toxicology.(Pergamon Press Inc.Maxwell House,Fairview Park,Elmsford,NY 10523) V.20-1982-Volume(issue)/page/year:35,605,1997.

 Daidzein:

 Chemical Name: 4H-1-Benzopyran-4-one,7-hydroxy-3-(4-hydroxyphenyl)-
 CAS: 486-66-8.Molecular Formula: C15-H10-O4.Weight: 254.25
 Beilstein No.:0231523(5-18-04-00089.Beilstein Handbook Reference)
 Synonyms: Daidzein;Daidzeol;4'7-Dihydroxyisoflavone;7,4'-Dihydroxyisoflavone;7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Isoflavone,4'7-dihydroxy-;K251b.

 Acute toxicity(LD50):

 LD-Lethal dose,Intraperitoneal.Rodent-mouse.>2gm(2000mg)/kg.
 Details of toxic effects not reported other than lethal dose value.
 Reference: PCJOAU Pharmaceutical Chemistry Journal(English Translation).Translation of KHFZAN.(Plenum Pub.Corp.,233 Spring St.,New York,NY 10013) No.1-1967-Volume(issue)/page/year:13,51,1979.


 Genistin:

 Chemical Name:4H-1-Benzopyran-4-one,7-(beta-D-glucopyranosyloxy)-3-(4-hydroxyphenyl)-
 CAS: 4529-59-9.Molecular Formula: C21-H20-O10.Weight: 432.41
 Beilstein No.:0064479(4-18-00-02732.Beilstein Handbook Reference)
 Synonyms:Genistein,7-beta-D-glucopyranoside;Genistein,7-O-beta-D-glucoside;Genistin;Genistine;Genistoside.

 Acute toxicity(LD50):

 LD50-Lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.>2gm(2000mg)/kg.
 Details of toxic effects not reported other than lethal dose value.
 Reference: PCJOAU Pharmaceutical Chemistry Journal(English Translation).Translation of KHFZAN.(Plenum Pub.Corp.,233 Spring St.,New York,NY 10013) No.1-1967-Volume(issue)/page/year:13,51,1979.

 Daidzin:

 Chemical Name:4H-1-Benzopyran-4-one,7-(beta-D-glucopyranosyloxy)-3-(4-hydroxyphenyl)-5-hydroxy-
 CAS: 552-66-9.Molecular Formula: C21-H20-O9.Weight: 416.41
 Beilstein No.:0059741(4-18-00-01808.Beilstein Handbook Reference)
 Synonyms:Daidzein 7-glucoside;Daidzein 7-O-glucoside;Daidzin;Daidzoside;7-(beta-D-Glucopyranosyloxy)-3-(4-hydroxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one.

 Acute toxicity(LD50):

 LD50-Lethal dose,50 percent kill.Intraperitoneal.Rodent-mouse.>2gm(2000mg)/kg.
 Details of toxic effects not reported other than lethal dose value.
 Reference: PCJOAU Pharmaceutical Chemistry Journal(English Translation).Translation of KHFZAN.(Plenum Pub.Corp.,233 Spring St.,New York,NY 10013) No.1-1967-Volume(issue)/page/year:13,51,1979.

Reference:

• The Secret of Soy,What is Soy Isoflavones?Function of Natural Genistein?Soy Bean Extract.

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♣ last edit date:08th,Oct.2010.