Ursolic acid:Actions,Commonly Known Benefit and Research.

Contents

• Basic Chemical Info.
• Basic Introduction and Botanical Info.
• Actions and Chemistry of Ursolic Acid.
• Commonly Known Benefit of Ursolic Acid.
• Pentacyclic Triterpenes (PCTs) as Inhibitors of Inflammation.
• Safety and Toxicity for Ursolic Acid.
• Administration and Dosage.
• Research Update of Ursolic acid.
• Photo Gallery of Ursolic acid Botanical Source

Administration and Dosage.:

Clinical use of ursolic acid as an isolate is new, but oleanolic acid, which is nearly identical in structure but apparently milder in action, has been used for some time. Effective daily doses of oleanolic acid, based on its application in treatment of hepatitis, are reported in the range of 75-300 mg/day.

 For a standard dried hot water extract of an herb, which may contain about 2% of the PCTs, that dosage corresponds to use of about 4-15 grams of the extract, a large amount. Additional information on dosage of compounds of this type (see: Platycodon and other herbs with triterpene glycosides) indicates that a daily dose of about 300 mg is safe and potentially useful for long term applications and 600 mg is safe at least for short term dosage.

 Dr. Acharan Narula describes use of 300-500 mg or oleanolic acid as an intestinal anti-inflammatory and recommends Olenoate, a product of oleanolic acid in capsules of 100 mg each. For ursolic acid, in vitro studies have shown that it is about twice as effective as an anti-inflammatory compared to indomethacin, a potent NSAID that is administered in doses of just 50-100 mg/day; however, when converted to actual human use, the dose of ursolic acid needed may prove higher.

 Boswellic acid, another PCT that inhibits 5-LOX, and is used as an anti-inflammatory for arthritis, Crohn's disease, and asthma, is administered in doses of 400 mg 3 times a day of an extract standardized to contain 37.5% boswellic acids, which corresponds to 450 mg/day of boswellic acid.

 In general, the PCT dosage for anti-inflammatory effects appears similar to the dosage of NSAIDS.

Reference:

• Ursolic acid:Actions,Commonly Known Benefit and Research.

This article written and edited via herbalist of MDidea Extracts Professional. They run a range of online descriptions about this herb,including general information related and summarized updating discoveries from findings of professional scientisits this field related.Describe style aimed to form a useful detecting literature space where the intertwined threshold and related questions raise out and visualize themselves.

♣ last edit date:08th,Oct.2010.