Wolfberry and Wolfberry extract.
- Basic Character and identification of Wolfberry.
- Plant Description of Wolfberry.
- Stem Cultivation,Seed reproduce,Fruit Preparation and Root Preparation of wolfberry.
- PhytoChemical Content of chinese wolfberry.
- Application and General Value of Wolfberry:
- 1.Character and Efficacy of chinese wolfberry.
- 2.Constituents and Pharmacology of wolfberry.
- 3.Ancient Medicine for Overall Wellbeing.
- 4.Natural Multi-nutrients of chinese wolfberry.
- 5.Function of Wolfberry Extracts and Wolfberry polysaccharides.
- 6.Wolfberry Extracts as good tumor inhibitor:Cancer prevention.
- 7.Wolfberry Extracts as good old man remedy.
- 8.Wolfberry Extracts as good kidney remedy.
- 9.Ancient literature registered wolfberry as a kind of herb medicine for anti-age.
- 10.Liver protection of Wolfberry Extracts.
- 11.Wolfberry and wolfberry extracts act as good remedy for hairdressing and skin care.
- 12.Wolfberry as good Hemopoiesis promoter.
- 13.Vision improvement function of wolfberry and wolfberry extracts.
- 14.Cholesterol reducer of wolfberry and wolfberry extracts.
- 15.Anti-aging function of wolfberry and wolfberry extracts.
- Functional Dosages of chinese wolfberry.
- Functional common taken method of chinese wolfberry.
- Safety and Acute Toxicity of LBP and LbGp.
- Where to source the best quality Chinese Wolfberry?
- How Search engine think about lycium?
- Wolfberry:Research Update
- Photo Gallery of Lycium barbarum.
4.10.Liver protection of Wolfberry Extracts.:
One study in China discovered that the hepaprotective component (zeaxanthin dipalmitate) from wolfberry helps counteract carbon tetrachloride induced hepatotoxicity.
Another study from China found LBP exerts hepaprotection through inhibiting the lipid peroxidation of liver cells in aging mice. LBP helps to repair liver cell injury induced by CCl4 and facilitates recovery from hepatic necrosis.
Liver Disease prevention and Hepatoprotective effects:
In 1974, it was reported that betaine could treat various chronic liver diseases; lycium fruit is often administered with another Chinese herbal fruit, schizandra, for that purpose. In recent years, betaine has been included in some Western nutritional supplement products, especially those used for improving muscle mass. Betaine is an alkaloid, sometimes classed as an amino acid, that is found also in capsicum, silybum (the source of the liver-protective flavonoid silymarin), and beets (Beta vulgaris, from which betaine gets its name). Betaine is used by the liver to produce choline, a compound which calms nervousness, enhances memory, and protects against fatty liver disease. In the sugar beet, which is the commercial source of the isolated compound, betaine is present at a level of 0.3-0.7%.
Some relative study identified antihepatotoxic cerebroside from Lycium chinense fruits,they are 1-O-beta-D-glucopyranosyl-(2S, 3R,4E,8Z)-2-N-palmitoyloctadecasphinga-4,8-dienine+ ++ (1) and 1-O-beta-D-glucopyranosyl -(2S,3R,4E,8Z)-2-N-(2'-hydroxypalmitoyl)octadecasph inga-4,8-dienine (2)(15.).Some relative study proposed that zeaxanthin dipalmitate which contains in Lycium chinense exerts a potent hepatoprotective activity against carbon tetrachloride induced hepatotoxicity,its mechanism is via inhibiting Ito cell proliferation, collagen synthesis and by inhibiting certain biochemical functions of Kupffer cells(17.).Some other test find that a novel cerebroside from wolfberry fruit named LCC(1-O-(beta-D-glucopyranosyl)-(2S,3R,4E,8Z)-2-N-palmityloc tadecasphinga-4,8-diene; LCC) may preserve the hepatic mitochondrial level of GSH by scavenging reactive oxygen species produced during CCl4-induced toxicity and thereby reduce lipid peroxidation and cellular damage(20.).Some other related study suggest that LCC may have prominent hepatoprotective activity,its mechanism got discussed(23.).Some pyrrole derivatives of the Lycium chinense fruits got find from some test that two of them showed hepatoprotective effects comparable to silybin at the concentration of 0.1 microM (64.4 and 65.8%, respectively)(44.).Some review study proposed that traditional herbs included Lycium chinense and others(S. marianum, Schisandra chinensis, Phyllanthus amarus, P. kurroa, A. paniculata, G. radix, Lycium chinense and Cochlospermum tinctorium) got used widely as hepatoprotectants(57.).Some CCl(4)-induced hepatotoxicity study find that Lycium chinense Miller (Solanaceae) fruit (LFE) pretreatment shown to possess a significant protective effect by lowering the serum aspartate and alanine aminotransferase (AST and ALT) and alkaline phosphatase (ALP). This hepatoprotective action was confirmed by histological observation.LFE also displayed hydroxide radical scavenging activity in a dose-dependent manner (IC(50) = 83.6 microg/ml),the result of this test suggested that the hepatoprotective effects of the LFE might be related to antioxidative activity and expressional regulation of CYP2E1(78.).Some relative study identified some new isolated as constituents from Lycium chinense fruits are considered as hepatoprotective glycolipid(96.).Some other study about Ischemia/reperfusion (I/R) of the rat liver got negative propose that in a comparation between lycium barbarum and ascorbic acid,in the I/R protocol induced oxidative and nitrosative stress and liver injury,Ascorbic acid showed significant protective effects on reperfusion liver injury by attenuating hydroxyl radical and NO release. In contrast, LB aggravated liver injury by increasing hydroxyl radical release(148.).In some liver oxidative injury of high-fat mice study proposed that administration of lycium barbarum polysaccharides significantly increased antioxidant enzymes activities and decreased MDA level in mice,these polysaccharides had IR bands at 800-1200cm(-1), 1450-1800cm(-1), 2500-3000cm(-1), and 3200-3600cm(-1), which were distinctive absorptions of polysaccharides,for the composition of these LBPs,mainly contained xylose and glucose,little amount of rhamnose, mannose and galactose was observed(152.).
Hepatic fibrosis inhibition:some study find that zeaxanthin dipalmitate (ZD), a carotenoid from Lycium chinense fruit,can effectively inhibited hepatic fibrosis in BDL rats, at least in part via its antioxidative activity,the tested concentration dosage is about 25 mg/kg body weight(35.).
Alcoholic fatty liver:Some alcoholic fatty liver test on 125 wister rats concluded that LBP can effectively prevent AFL(Alcoholic Fatty Liver),the mechanism may be due to its effects in inhibiting the hepatocyte CYP2E1 expression and prevention of lipid peroxidation.Five and Ten week study tested result showing that levels of CYP2E1 gene and protein expression,the activity of serum AST, liver MDA, significantly lower than those of the alcohol group,and the activity of SOD were all significantly higher(113.).
Another plant in the Solanaceae family, Physalis angulata, contains physalin (one of the lycium ingredients) as a major active component. The herb is used as a treatment for hepatitis B. Extracts of physalis have been shown to increase splenic natural killer cell activity in normal and tumor-bearing mice, with anticancer effects for several cancer lines.
Like other commonly eaten fruits, lycium is non-toxic. Toxicity studies showed that injection of 2.4 grams/kg of lycium fruit extract did not cause adverse reactions, but at the huge dosage of 25 g/kg, toxic reactions were rapid. The LD50 was determined to be about 8.3 grams/kg (about one pound of the dried fruit, extracted and injected, for a human).
- 1.Wolfberry and Wolfberry extract.
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