Eucommia Bark Dosage and Administration.

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Eucommia Bark Dosage and Administration.

Eucommia Bark Cortex Eucommiae Eucommia Ulmoides Cortex Eucommia ulmoides oliv  10-15g (Decoction.boiled in water for oral use),The traditional amount of eucommia bark is 10-15 grams, boiled in water for oral use.Stir-baked eucommia has better effects than the unprepared.The stir-fried bark is stronger than raw bark to lower blood pressure, and a decoction is stronger than a tincture.
 The fried herb is more effective than the raw herb. Eucommia bark (Duzhong) is contraindicated in cases with deficiency of yin with excessive fire.
 Contraindications: There has never been a case of overdosing on Eucommia recorded in the literature (over a period of more than twenty-five hundred years).
 Precautions: It should not be used in cases of hyperac-tivity of fire due to yin deficiency. Patients with hyperactive fire and yin deficiency should use this herb with caution.

 Eucommia Bark.:Toxicity Study

 Toxicity of Eucommia Bark extract:

 No death or changes in physical conditions resulted from administering alcohol-based extract of Du Zhong to mice at 40g/kg for three consecutive days.Reference:Zhu Li Qing, et al. Journal of Chinese Materia Medica. 1986;17(12):15.

 Neither does death result from a one-time gastrolavage of water-based extract of Du Zhong at the dosage of 120g/kg.Reference:Li Xian Ping, et al. Journal of Chinese Patented Medicine Research. 1988;(1):15-16.
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 Identification of Chlorogenic acid:

 Eucommia Bark Cortex Eucommiae Eucommia Ulmoides Cortex Eucommia ulmoides olivChemical Name:Cyclohexanecarboxylic acid,3-((3-(3,4-dihydroxyphenol)1-oxo-2-propenyl)oxy)-1,4,5-trihydroxy-,(1S-(1-alpha,3-beta,4-alpha,5-alpha))-
 CAS RN.:327-97-9. M.F.Molecular Formula.C16-H18-O9. Molecular Weight.M.W.354.34 RTECS:GU8480000 EINECS:206-325-6.

 Synonyms:3-Caffeoylquinic acid;3-O-Caffeoylquinic acid;Chlorogenic acid;(1S,3R,4R,5R)-3-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid; 3-O-Caffeoylquinic acid; 5-O-(3,4-Dihydroxycinnamoyl)-L-quinic acid
 Note:Mutagen,Reproductive Effector,Natural Product.
 Melting point:205-209 deg C. alpha:-36 (c=1, H2O) Water solubility:soluble in hot water.

 Acute Toxicity of Chlorogenic acid

 LDLo-Lowest published lethal dose.Intraperitoneal.Rodent-rat.4 gm(4000mgs)/kg.
 Details of toxic effects not reported other than lethal dose value.
 Reference:TXAPA9 Toxicology and Applied Pharmacology.(Academic Press,Inc.,1E.First St.,Duluth,MN 55802)V.1-1959-Volume(issue)/page/year:36,227,1976.

 Reproductive Date:Chlorogenic acid
 TDLo-Lowest published toxic dose.Intraperitoneal.Rodent-rat.40 mg/kg.Sex/Duration:female 5~12 day(s) after conception.
 Reproductive-Specific Developmental Abnormalities-musculoskeletal system.
 Reference:TXAPA9 Toxicology and Applied Pharmacology.(Academic Press,Inc.,1E.First St.,Duluth,MN 55802)V.1-1959-Volume(issue)/page/year:36,227,1976.
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 Mutagenic Date:Chlorogenic acid

 Eucommia Bark Cortex Eucommiae Eucommia Ulmoides Cortex Eucommia ulmoides olivGene conversion and mitotic recombination.Yeast-Saccharomyces cerevisiae.1 gm/L.Reference:MUREAV Mutation Research.(Elsevier Science Pub.B.V.,POB 211,1000 AE Amsterdam,Netherlands)V.1-1964-Volume(issue)/page/year:135,109,1984.

 Mutation in microorganisms.Rodent-mouse Lymphocyte.6545 mg/L.Reference:MUREAV Mutation Research.(Elsevier Science Pub.B.V.,POB 211,1000 AE Amsterdam,Netherlands)V.1-1964-Volume(issue)/page/year:204,219,1988.

 Cytogenetic analysis.Rodent-hamster Ovary.250 mg/L.Reference:MUREAV Mutation Research.(Elsevier Science Pub.B.V.,POB 211,1000 AE Amsterdam,Netherlands)V.1-1964-Volume(issue)/page/year:111,209,1983.
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Reference:
  • 1.Eucommia bark,Duzhong and its Applicable Uses.

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