Turmeric Root or Curcuma Root,Phytochemicals and Applications.

Contents

• Basic Botanical Data and Identification of Turmeric Root.Curcuma Root.
• Description of Turmeric Root.Curcuma Root.
• Origin of Curcuma root.
• Curcuma Root Appearance and characters.
• Powdered plant material of Curcuma Root.
• Chemical assays and Phytochemicals of Turmeric Root.Curcuma Root.
• Medicinal uses of Turmeric Root.Curcuma Root.
• Experimental pharmacology of Turmeric Root.Curcuma Root.
• Functions of Turmeric Root.Curcuma Root.
• Curcuma Root Suggestions and Administrations.
• Literature from Chinese historical sources:Curcuma Root.
• Modern Researches of Turmeric Root.Curcuma Root.
• Curcuma longa Common Application.
• Dose escalation of a curcuminoid formulation.
• Effect of Curcuma longa and Ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury.
• Quality control including chromatographic fingerprint profiling.
• Research Update:Curcumae Longae.Curcuma longa.

Curcuma Root Suggestions and Administrations.:

Precautions and contraindications:

 Not enough is known about how turmeric might affect an infant to recommend its supplemental use while breast-feeding. Eating the amounts of turmeric that would be used in cooking are not believed to present a danger.

 Contraindications:

 Obstruction of the biliary tract. In cases of gallstones, use only after consultation with a physician. Hypersensitivity to the drug.Curcuma longa should not be used during pregnancy

 Dosage and Administration: 6-12 g. Decoct or grind into powder for oral administration.Deflatulance: Taken 0.5-1.0 g four times a day after meals and at bedtime.
 

 Safety data:

 Acute and subchronic toxicity of tumeric was tested in mice and wistar rats, respectively. Tumeric powder produced no acute toxicity in mice when given at the dose of 10g/kg body weight. LD50 of ethanolic extract in mice was more than 15g/kg either by p.o., s.c. or i.p. administration. Subchronic toxicity of tumeric powder at 0.03, 2.5 and 5.0g/kg/day was investigated for 6 months in 96 wistar rats. Male rats treated with 2.5 and 5.0 g/kg/day of tumeric powder had a reduction in food consumption and growth rate as compared to the control animals or those treated with 0.3 g/kg/day of the drug. No evidence of other abnormalities has been observed (Sittisomwong et al., 1990).


 Risks:

 Kawanishi et al. (2005) remark that curcumin is a "double-edged sword" having both anti-cancer and carcinogenic effects.Carcinogenic effects are inferred from interference with the p53 tumor suppressor pathway, an important factor in human colon cancer.Carcinogenic and LD50 tests in mice and rats, however, have failed to establish a relationship between tumorogenesis and administration of curcumin in turmeric oleoresin at 98% concentrations.This may prove curcumin medicinally useful as it helps activate p53. When a cell is inhibited by cancer the concentrations of p53 increase, helping cells defend against cancer mechanisms[citation needed]. But it may also suppress p53 levels, preventing cells from initiating defensive mechanisms, a response seen only in certain diseases

 Safety and Toxicity of Curcuma Oil:

 RTECS:GS3774080;chemical Name:Curcuma oil;CAS RN:8024-37-1.Note:Tumorigen,Mutagen,Primary Irritant.
 Synonyms:Curcuma longa oils,Oil of turmeric,Oils,curcuma;Tuermeric oil;Turmeric oleoresin;

 Curcuma Oil:Skin/Eye Irritation data

 Standard Draize test.Administration onto the skin,Rodent-rabbit,dose/period:500 mg/24 H,Reaction severity:Mild.Reference:FCTOD7 Food and Chemical Toxicology.(Pergamon Press Inc.,Maxwell House,Fairview Park,Elmsford,NY 10523) V.20-1982-Volume(issue)/page/year:21,839,1983.

 Curcuma Oil:Acute Toxicity

 LD50,Lethal dose,50 percent kill.Oral,Rodent-rat.> 5 grams/kg.Details of toxic effects not reported other than lethal dose value.

 LD50-Lethal dose,50 percent kill.Administration onto the skin.Rodent-rabbit.>5 grams/kg.Details of toxic effects not reported other than lethal dose value.Reference:FCTOD7 Food and Chemical Toxicology.(Pergamon Press Inc.,Maxwell House,Fairview Park,Elmsford,NY 10523) V.20-1982-Volume(issue)/page/year:21,839,1983.

 Curcuma Oil:Other Multiple Dose Toxicity Data:

 TDLo-Lowest published toxic dose.Oral.Rodent-rat.27300 mg/kg/13W-C.Toxic Effects:Liver-changes in liver weight;Blood-other changes.

 TDLo-Lowest published toxic dose,Oral.Rodent-mouse.13650 mg/kg/13W-C.Toxic Effects:Liver-changes in liver weight.Reference:NTPTR*National Toxicology Program Technical Report Series.(Research Triangle Park,NC27709)No.206-Volume(issue)/page/year:NTP-TR-427,1993.


 Tumorigenic Data:

 TDLo-Lowest published toxic dose.Oral.Rodent-rat.72800 mg/kg/2Y-C.Toxic Effects:
 Tumorigenic-equivocal tumorigenic agent by RTECS criteria.
 Reproductive-Tumorigenic effects-other reproductive system tumors.

 TDLo-Lowest published toxic dose.Oral.Rodent-mouse.437 mg/kg/2Y-C.Toxic Effects:
 Tumorigenic-equivocal tumorigenic agent by RTECS criteria.
 Gastrointestinal-tumors.
 Liver-tumors.
 Reference:NTPTR*National Toxicology Program Technical Report Series.(Research Triangle Park,NC 27709)No.206-Volume(issue)/page/year:NTP-TR-427,1993

 Mutagenic Data:

 Cytogenetic analysis.Human Lymphocyte.6 mg/L.
 Cytogenetic analysis.Rodent-mouse Cells-not otherwise specified.50 mg/L/4H (Continuous)
 DNA inhibition.Rodent-hamster Fibroblast.10 mg/L.
 Cytogenetic analysis.Rodent-hamster Fibroblast.50 mg/L/4H (Continuous)
 Cytogenetic analysis.Mammal-species unspecified Cells-not otherwise specified.10 mg/L/4H.
 Reference:FCTXAV Food and Cosmetic Toxicology.(London,UK)V.1-19,1963-81.For publisher information,see FCTOD7.Volume(issue)/page/year:14,9,1976

 Data in USA:

 EPA TSCA Section 8(b) Chemical Invention.
 NTP Carcinogenesis studies(feed);equivocal evidence:mouse.
 NTP Carcinogenesis studies(feed);equivocal evidence:rat.
 Reference:NTPTR*National Toxicology Program Technical Report Series.(Research Triangle Park,NC 27709)No.206-Volume(issue)/page/year:NTP-TR-427,93.

Reference:

• 1.Turmeric Root or Curcuma Root,Phytochemicals and Applications.

This article written and edited via herbalist of MDidea Extracts Professional. They run a range of online descriptions about this herb,including general information related and summarized updating discoveries from findings of professional scientisits this field related.Describe style aimed to form a useful detecting literature space where the intertwined threshold and related questions raise out and visualize themselves.

♣ last edit date:18th,Oct.2010.