Common Uses and applicatin of Hoary willowherb,Epilobium parviflorum.
- Basic Botanical Information and Identification of Hoary willowherb,Epilobium parviflorum.
- Botanical Description of Hoary willowherb,Epilobium parviflorum.
- Willow Herb Species and Epilobium Classifications:Identification and Differentiations.
- Tradition and History of Hoary willowherb,Epilobium parviflorum.
- Phytochemicals and Constituents of Hoary willowherb,Epilobium parviflorum.
- Common Uses and Applicatin of Hoary Willow-herb(Epilobium parviflorum) and Rose Bay Willow-herb(Epilobium angustifollum).
- Hair Growth and Hoary willowherb.Epilobium parviflorum.
- Willowherb Herbal Alternative to Finasteride-as a Natural Anti-Androgen.
- Suggestions and Administrations of Willowherb.
- Research Update:Willow Herb,Epilobium Parviflorum,Epilobium Angustifolium and others.
Common Uses and Applicatin of Hoary Willow-herb(Epilobium parviflorum) and Rose Bay Willow-herb(Epilobium angustifollum).
Epilobium angustifolium L.(Rose Bay Willow-herb) is a circumpolar member of the evening-primrose family (Onagraceae).
The plant is an abundant perennial that dominates many plant communities undergoing succession, quickly reclaiming disturbed ground such as cut or burned forest, thus explaining its common name, fireweed. It is also commonly known as rosebay willowherb and great willowherb. Willowherb is often employed as the English name for the worldwide species. Canadian Willowherb? has been used to describe the plant growing in Canada, which appears to possess distinct characteristics from the European plant.
Although sometimes considered a weed, it has a long history of use as both a food and a medicinal.
Historically, medicinal use includes oral use of the plant extracts, often in the form of an infusion or tea, as a treatment for prostate and urinary problems including benign prostatic hyperplasia (BPH) or enlarged prostate; and for various gastrointestinal disorders such as dysentery or diarrhea. Topically the plant has been used traditionally as a soothing, cleansing and healing agent to treat minor burns, skin rashes, ulcers, and numerous other skin irritations and afflictions.
The most tangible commercial applications of Epilobium angustifolium to date appear to be those related to the topical use of the extracts for their potent anti-irritant, anti-inflammatory, and free radical-scavenging effects. Commercial extracts of the plant are widely used in cosmeceuticals and personal care products ranging from creams, lotions, and shampoos to hair tonics and baby wipes. Therapeutic products for various skin conditions such as those for eczema, psoriasis, seborrhea, fungal infections, and rosacea have incorporated willowherb as a functional active ingredient. The main nutraceutical, cosmetic and therapeutic uses of willowherb and its extracts have, over the past 20 years, received scientific support and are explainable, at least in part, by the unusual chemical make-up of the plant.
Willow Herb Traditional Uses.
In herbal history, the herb seems to have been insignificant, with very little reference or use. The plant is mentioned in a Pharmacopoeia of 1880. Maria Treben in her herbal, 'Health through God's pharmacy' (published 1982) shares her experience of her father-in-law's death from hypertrophy of the prostate gland. An elderly neighbour told her of this plant and its varied uses, and suggested Maria may be able to help many people with the knowledge. Maria did just that, and went on to help many people with information of the herb. In her second book, 'Cures', she shares many case histories and inspiring testimonials of people regaining their health. Maria found that the herb resulted in relief from many prostate disorders. As people were helped by Maria, with the information of using the herb for all manner of kidney, bladder and prostate problems, they passed on the information to others: of a simple remedy that relieves discomfort and pain.
First Nations used fireweed externally for burns and other skin conditions, and drank it as a tea for gastro-intestinal and bronchial problems. Many early settlers from Europe already used native European Epilobium species for similar purposes and so quickly accepted the North American plant.
Traditional uses:Antibacterial,Anti-inflammatory,Antimicrobial,Antioxidant,Benign Prostatic Hyperplasia (BPH),Bladder Health Maintenance,bronchial infections,Cellular Regeneration,Cleansing,Detoxification,diarrhea,Enlarged prostate, prostatitis, kidney or bladder disorders, gastro-intestinal disorders,Hormonal Imbalances,irritable bowel syndrome,Male Health Maintenance,mouth mucus membrane lesions, menstrual disorders,Prostate Health Maintenance,cystitis, even, urinary infections,Urinary System Problems,mucous colitis, rectal bleeding,and can be made into an ointment to soothe skin problems in children.
Epilobium parviflorum has been used for a long time as a medicinal plant for the treatment of various prostate symptoms, like prostate adenoma and associated disorders. Epilobii herba, willow herb, has not been officially recognized by any of European pharmacopoeias. Epilobii herba contains various pharmacologically-useful compounds, such as polyphenols, among which are the flavonoids: quercitrin, rutin, isoquercitrin, isomyricitrin and myricitrin. The total polyphenol and flavonoid contents were determined in crude willow herb drugs. A high linear correlation was observed between the total phenolic content and the reducing power of the samples. Epilobii herba showed marked activity as a radical scavenger, indicating that it has effective activities as hydrogen donors and primary antioxidants to react with lipid radicals.
Genitourinary Conditions:bladder cancer,cystitis,kidney and bladder problems,urinary tract disorders.
Male Conditions:complaints which often occur after a prostate gland operation, including burning sensation on urination,disorders of the prostate gland combined with Saw Palmetto Berries,hypertrophy of the prostate gland.
Action:anti-inflammatory,astringent,prostatelium,agent to eliminate prostate disorders.
Medicinal virtues: This is cooling and astringent. The fresh juice or the powdered root is taken to stop internal haemorrhaging. They stop looseness of the bowel and other fluxes and also nocturnal pollutions.
Modern uses of Willow Herb.
This remedy has been discarded by professional herbalists as the use of the leaves has been associated with poisonings and convulsions.In addition to its medicinal uses, fireweed shoots can be eaten as a vegetable, while the young leaves can be added to salads.
Small-flowered willowherb, Epilobium parviflorum SCHREBER [Fam. Onagraceae], is widespread in Central and Eastern Europe and in disturbed areas of North America. Epilobium species have been used as remedies in folk medicine, particularly in Central Europe, for the treatment of prostate disorders and abnormal growths. This pleasant herb and flower tea was highly recommended by Austrian herbalist, Maria Treben, for ailing men with prostate abnormalities. Based on customer feedback to health food stores and companies in Canada and the U.S., small-flowered willowherb quickly helps men to recover from the annoying symptoms of prostatitis. Preliminary (in vitro) studies at the Prostate Center of Vancouver found that very low concentrations of an extract from small-flowered willowherb tea, in the micrograms per ml level, was among the most active ever seen against abnormal cells and growths of the prostate. Several extracts from Epilobium parviflorum, were evaluated in biochemical assays with 5-alpha-reductase and aromatase, two enzymes involved in the etiology of benign prostatic hyperplasia (BPH).
A decoction is made from the dried and powdered root for digestive disorders accompanied by diarrhoea. It is soothing and astringent. The dried leaves can be used as a tea and are also demulcent and astringing. The herb, dried and infused is indicated in the treatment of whooping cough and asthma.
Willow Herb Anti-Cancer.
A special elagitannin, oenothein B, is present in the plant and appears to be an active anti-inflammatory component. The reported anti-cancer activity of willowherb extract may be related to the content of oenothein B, which has been found to exhibit potent anti-tumor properties, as well as cause inhibition of the 5-alpha-reductase enzyme.
This explains the antihyperandrogenic effects that may be useful in the prevention and treatment of BPH, as well it supports the use of the extract in the prevention and treatment of prostate cancer. Scientific research has revealed the potential of oenothein B or similar compounds as useful antiviral and anticancer chemotherapeutic agents. The anti-cancer and analgesic properties of willowherb extract have been the subject of recent investigations, where significant activity has been found.
Anti-Cancer Related Research:Characterization of the Effect of Epilobium Extracts on Human Cell ProliferationKarger.Vol. 69, No. 2, 2003.Annabella Vitalonea, Janice McCollb, Dean Thomeb, Lucio G. Costac,d, Beatrice Titaa
Abstract:We have previously shown that extracts of different Epilobium species, a phytotherapeutic agent used in folk medicine as a treatment for benign prostatic hyperplasia, inhibit proliferation of human prostate cells. The selectivity of this effect was evaluated in four different human cell lines (PZ-HPV-7, normal prostate cells; LNCaP, transformed prostate cells; HMEC, mammary cells, and 1321N1, astrocytoma cells). Different extracts of Epilobium species (E. rosmarinifolium, E. spicatum, and E. tetragonum) had similar growth-inhibitory effects in all cell lines tested, indicating a lack of specificity for prostate cells. Inhibition of DNA synthesis was mostly due to the nonpolar fraction of the extracts which is expected to contain flavonoids and sterols. Polar fractions were devoid of activity with the exception of that from E. rosmarinifolium.
This species is the most potent in the antiproliferative effect and contains the highest concentration of oenothein B, a hydrolyzable ellagitannin. Oenothein B inhibited DNA synthesis in all four cell lines tested. Extracts of E. angustifolium (the Linne denomination of E. spicatum) and of E. spicatum from different sources were compared for their ability to inhibit DNA synthesis and for their oenothein B content. The E. angustifolium extract contained an amount of oenothein B 40-fold higher than the other extract of the same species and was ten times more potent in inhibiting DNA synthesis in a human prostate cell line. These results indicate that Epilobium extracts inhibit proliferation of prostate cells in a nonspecific manner. Oenothein B may play a role in this effect, but other active compounds are also present. The difference observed between extracts from the same species underscores the importance of determination and standardization of active ingredients in phytotherapeutic agents.
Anti-Inflammatory Effects of Epilobium angustifolium vs. Epilobium parviflorum.
Scientific literature is quickly confirming the actions of Epilobium. In 1991, an article in Plant Medicine1 confirmed its anti-inflammatory effect, and noted it to be "ten times more effective than indomethacin."
Aqueous extracts displayed inhibition of these enzymes and the active compounds identified were macrocyclic ellagitannins, oenothein A1, B1 and B2, which can make up to 14% of crude plant extracts. Out of a total of 92 plant phenolic extracts tested, small-flowered willowherb was also found to have high antioxidant activity. Small-flowered willowherb tea is also recommended for treating urinary tract infections in women. In one study, both the large-flowered willowherb (Epilobium angustifolium) and small-flowered willowherb E. parviflorum were found to reduce inflammatory prostaglandins in the carrageenin-induced rat paw edema test; in this study, E. angustifolia was found to be 5 times more powerful than E. parviflori. Antimicrobial screening of 13 phenolic substances and 29 extracts prepared from Finnish plant materials against selected microbes found that willowherb (Epilobium angustifolium L.) was one of the most active plant extracts tested against bacteria.
Epilobium (Small Flowered Willow Herb) only recently came to the professional's and public's attention, after a lecture by Austrian herbalist Maria Treben. However, her lecture stirred a tremendous demand for the herb throughout Germany and Austria for use by men concerned about the health of their prostate. American demand has grown quickly over the past few years, even in light of little public information about the herb, because both men and women experience its benefits. Until now, there have been few reliable sources for Epilobium, and no convenient full-spectrum forms of the herb.
Willowherb extracts possess antimicrobial effects against a number of bacteria, including recently discovered activity of the Willowherb extract, along with isolated constituents, against the bacteria, Propionibacterium acnes. Myricetin 3-0-glucuronide has been identified as one of the anti-inflammatory components of willowherb.
Invention provides medicaments comprising an oenothein, including topical formulations for use as free radical scavengers, or to treat irritation, or to treat inflammation. The oenothein for use in such formulations, such as oenothein-A or oenothein-B, may be purified from natural sources, such as plant material (e.g. Epilobium angustifolium).
Oenothein Application for treatment of inflammation, irritation and the effects of free radicals:US Patent 6528490
Ellagitannins are a diverse family of naturally-occurring compounds consisting of a central core of glucose esterified with hexahydroxydiphenic acid. Ellagitannins are known as active constituents of a variety of medicinal plants (Okuda and Hotano, 1989, Planta Med. 55(2):117). For example, U.S. Pat. No. 5,843,911 issued Dec. 1, 1998 discloses the use of ellagitannins having galloyl and hexahydroxydiphenoyl substituents as hyaluronidase enzyme inhibitors for topical application, to enhance water retention in skin by preventing the hydrolysis of hyaluronic acid. The ellagitannins disclosed in U.S. Pat. No. 5,843,911 are identified as "GOD-type" ellagitannins, extractable from a variety of plants.
U.S. Pat. No. 5,525,594 issued Jun. 11, 1996 discloses the use of the ellagitannin oenothein-B (which is not a "GOD-type" ellagitannin as defined in U.S. Pat. No. 5,843,911) for the treatment of hyperandrogenic disorders by oral, rectal or parenteral administration (also reported in Lesuisse et al., 1996, J. Nat. Prod. 59(5):490). In this treatment, the mechanism of action of oenothein-B is taught to be the inhibition of 5-reductase, an enzyme responsible for the conversion of testosterone to dihydrotestosterone. Both oenothein-A and oenothein-B from Epilobium species have been shown to have similar pharmocologic activity, evidenced by 5-reductase and aromatase inhibition (Ducrey et al., 1996, Planta Medica 63:111). It is disclosed in U.S. Pat. No. 5,525,594 that oenothein-B may be extracted from various Onagraceae plants (evening-primrose family), including Epilobium parviflorum. Ducrey et al., 1996, supra, disclose the extraction of oenotheins-A and B from E. capense, and the quantitation of oenothein-B in a variety of old world Epilobium species, including Old World E. angustifolium L (Rosebay Willowherb). The apparent antiviral and antitumour activities of oenothein-B are also discussed by Ducrey et al., 1996, supra, and in U.S. Pat. No. 5,525,594.
Aqueous extracts of Old World Epilobium angustifolium have been suggested for use as oral anti-inflammatories (German Patent No. 3,605,250 of Jul. 16, 1987), and the active ingredient in such extracts has been identified as the flavonoid compound myricetin glucuronide (3,3'4',5,5',7-hexahydroxyflavone-3-O-glucuronide; see Hiermann et al., 1991, Planta Medica 57:357 and German Patent 3,900,023 of Jul. 12, 1990).
It has previously been disclosed, by the present inventors, that crude aqueous extracts of New World Epilobium angustifolium (Canadian Willowherb) have anti-irritant and anti-inflammatory properties when applied to human skin.
Exposure of skin to sunlight can cause inflammation directly as a result of the harmful effects of ultraviolet light. In the presence of atmospheric oxygen, sun-exposed skin may also be indirectly damaged by exposure to free radicals of oxygen generated by solar radiation. There remains a need in the art for compounds that may be used to treat inflammation, irritation and exposure to free radicals.
It has surprisingly been discovered that oenotheins are potent topical anti-inflammatories, anti-irritants and free radical scavengers (useful for treating exposure to free radicals). These activities provide unexpected advantages in topical formulations or medicaments, for example to ameliorate the effects of sunlight on skin. Accordingly, the invention provides formulations comprising an oenothein, including formulations for topical use as free-radical-scavengers or as a prophylactic against damage caused by sunlight or other ionizing radiation, or to treat irritation and inflammation (including irritation and inflammation caused by exposure to sunlight or other agents). The oenothein for use in such formulations may for example be oenothein-A or oenothein-B. The oenothein may be purified from natural sources, such as plant material, or it may be prepared synthetically.
Other aspects of the invention include methods of formulating topical medications for treatment of inflammation, irritations or exposure to free radicals, comprising adding a known amount of an oenothein to such compositions (prior to the present invention, there was no motivation to determine the amount of oenothein being administered in herbal remedies, such as Epilobium angustifolium extracts). In light of the present invention, plant extracts for use in such formulations may now be assayed to determine the concentration of oenothein in the extracts so that dosages may be formulated more reliably. For example, New World Epilobium angustifolium extracts may be assayed for oenothein-B content. Packaging for formulations of the invention may include text that indicates that the formulations are useful for prophylaxis of sunlight induced damage, as free radical scavengers for treating exposure to free radicals, or for treating inflammation or irritation, such text may optionally disclose that the formulations contain an oenothein.
In another aspect of the invention, new plant extracts found to contain an oenothein may be used topically to ameliorate the effects of sunlight, as anti-irritants, as anti-inflammatories, or for treating exposure to free radicals. For example, Epilobium spp. other than Epilobium angustifolium may be used for making such extracts where they contain oenothein-A or oenothein-B or mixtures thereof.
Willow Herb Control Incontinence.
Clinical use has reported reduction in incontinence in both males and females.
5-alpha-reductase inhibition:Oenothein A and Oenothein B substitute Finasteride
Recent biological testing by Ducrey and Hartmann proved that the tannins Oenothein A and Oenothein B are extremely potent inhibitors of 5-a-reductase ( which metabolises testosterone into dihydrotestosterone ) and aromatase ( which converts testosterone into 17-B-estradiol ).In the case of Aromatase Oenothein A showed an inhibition of 70 % at 50 uM during in vitro testing. Against 5-a-reductase Oenothein A had a 50 % reduction at only 1.24 uM and Oenothein B a 50 % reduction at 0.44 uM. Finasteride shows the same result at 5 nM. This leads to the conclusion that Oenothein B is a potent 5-a-reductase inhibitor but not as strong as Finasteride.
A German research study confirmed that epilobium contains the active beta-sistosterol, a plant hormone that is the active component in Saw Palmetto - a known and proven 5-AR inhibitor.
But why is the Aromatase inhibiting function of Oenothein B so important? The inhibition of DHT increases the conversion of Testosterone into Estrogen with the help of Aromatase. . A decrease in DHT allows free testosterone to be converted to Estrogen because the DHT has been shut off. A 90 % block of DHT increases the free Testosterone by up to 30 %. Estrogen in men itself inhibits the production of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and follicle-stimulating hormone (FSH). As estrogen increases and testosterone decreases many men become prone to gynocomastia, increased body fat and body hair and much lower sex drive. The only way to avoid this is taking an aromatase inhibiter. Oenothein B does provide you with the best of both worlds. A very effective 5-AR and Aromatase inhibition in one product without any side effects.
Willow Herb used to improve BPH.
Essential fatty acids found in flax oil, evening primrose oil, pumpkin seed oil, and wheat germ oil which improve BPH.
For non vegetarians limit your source of animal fats to fish or chicken. A good source of zinc are pumpkin seeds, traditionally used in Germany as part of program for BPH which includes an incredibly effective plant called Small Flowered Willow Herb.
Willow Herb as Prostate Supplement:Prostate Health Prostatelium.
The Facts about Prostate Symptoms:Prostate problems affect more than half of men over 40. From this age on, the frequency of prostate disorders increases. Prostate cancer is the most common cancer in men, after skin cancer, and will affect nearly 221,000 men in the United States this year. About 29,000 men will die of the disease. There are two other medical problems that can arise with the prostate other than cancer; benign prostatic hyperplasia and prostatitis. Benign prostatic hyperplasia, or swelling of the prostate (enlarged prostate), causes symptoms such as urgency to urinate, low or interrupted urinary flow, and frequent night urinations. Prostatitis, which is less common, is a chronic bacterial infection of the prostate. This infection can also cause problems with the urethra and bladder.
Symptoms of An Enlarged Prostate:
Tired of frequent, night time bathroom trips that interrupt your sleep?
Annoyed by frequent bathroom trips that interfere with your day?
Pushing or straining when you try to urinate?
Feeling that your bladder doesn't completely empty while urinating?
Experiencing a weak stream, that stops and starts when you urinate?
Experiencing painful urination?
Expelling foul smelling urine?
Troubled by a loss of sex drive?
Epilobium Parviflorum has an inflammation-inhibiting and healing effect on acute and chronic inflammation of the prostate and can help to reduce the gland to its normal size. It is recommended that all men over the age of 50 take this herb regularly as a preventative and to maintain prostate and bladder health.
Inhibition of 5 alpha-reductase and aromatase, which are involved in the etiology of benign prostatic hyperplasia (BPH), was confirmed in several recent articles.2,3 In addition, the anti-infectious activity of a water-alcohol extract of epilobium was shown in vitro (outside the body), in ovo (in an egg) and in vivo (in a living body).4
Small Flowered Willow (Epilobium parviflorum), a member of the Evening Primrose family, one that I have a lot of experience with over the years. The whole herb is used medicinally as a tea or tincture.
It is a prostate tonic, diuretic and anti-inflammatory used for the genito-urinary system, kidney, bladder and prostate problems. Some of the conditions that respond to this herb are enlarged prostate, inflammation of the prostate and urethra, and cancer of the prostate and bladder.
Small flowered Willow herb is best taken in tea form with a dose of 2 cups daily 1/2 hour before breakfast and dinner and taken up to 3 months. One teaspoon to a cup boiling water, steep 10 minutes and strain out the herb.
The Solution:Prostate Herb Supplement and Willow Herb.
Prostaid contains one powerful ingredient different from most other prostate treatments on the market, that is organically grown prostate herb - Small Flowered Willow Herb. This potent herb has positive effects on prostate symptoms. It's anti-inflammatory properties work quickly to shrink enlarged prostate. At the same time the actives such as b-sitosterol in the herb work to promote healthy cells and restore proper function to both urinary and reproductive systems.
Enlargement of the prostate is considered one of the most common disorders occurring in men over 50. If left untreated, continued enlargement of the prostate eventually obstructs the bladder completely and emergency measures may become necessary. Fortunately help is at hand, Epilobium Parviflorum is a small obscure herb, which causes absolutely no side effects and is the most effective and yet completely harmless herbal medicine for disorders of the prostate.
Willow-herb (Epilobium ) settle urinary problems, unlike cranberry this is not thought to be able to work on infections but does ameliorate urinary discomfort and reduces difficulty in passing water. Please note that anyone experiencing urinary discomfort should visit a doctor as it is frequently a symptom of something more serious.
Quick Effects:The quick action of Small Flowered Willow Herb (Epilobium parviflorum) on prostate symptoms occurs within a few days to weeks, whereas other natural supplements can take months.
Willow Herb used as Skin cleansers.
Epilobium angustifolium extract got derived from a plant commonly known as fireweed or willow herb. Can have antimicrobial and anti-irritant properties for skin.Epilobium angustifolium L. is a circumpolar member of the evening-primrose family (Onagraceae). The plant is an abundant perennial that dominates many plant communities undergoing succession, quickly reclaiming disturbed ground such as cut or burned forest, thus explaining its common name, fireweed. It is also commonly known as rosebay willowherb and great willowherb.
Since time immemorial, the peoples of the forest regions of Canada have used the juices of Willowherb(Epilobium angustifolium) as skin cleansers, fresheners and soothers for irritated areas of the skin. There are abundant ethnobotanical anecdotes concerning the beneficial effects of this substance on irritated skin.
Commercial extracts of the plant are widely used in cosmeceuticals and personal care products ranging from creams, lotions, and shampoos to hair tonics and baby wipes. Therapeutic products for various skin conditions such as those for eczema, psoriasis, seborrhea, fungal infections, and rosacea have incorporated willowherb as a functional active ingredient. The main nutraceutical, cosmetic and therapeutic uses of willowherb and its extracts have, over the past 20 years, received scientific support and are explainable, at least in part, by the unusual chemical make-up of the plant.
Rose Bay Willow-herb Extract(Epilobium angustifolium L) and Oenothein-B play as principle bioactive molecule found in fashionable skin care cosmetics for acne treatment etc. This molecule has been patented for its wide ranging bioactivity including anti-viral, antitumour, and anti-hyperandrogenic applications and has also demonstrated free radical scavenging ability. Rose Bay Willow-herb Extract(Epilobium angustifolium L) extract has also been shown to effectively kill the P. Acne bacterium associated with acne.
Epilobium angustifolium (Rose Bay Willow-herb,Fireweed) contains a bioactive molecule: Oenothein-B, patented for its wide ranging anti-inflammatory, non-steroidal activity. Its antiviral, anti-tumor and free radical scavenging properties soothe inflamed or irritated skin while allowing healing to take place. The potent bioactivity makes it a therapeutic product recommended for irritated, red skin. Research performed in North America and Europe has found it outperforms 1% hydrocortisone in results measured: _ hour, 1 hour, 4 hours, and 24 hours. The Willowherb lotion was especially effective during the first three measured points of the test, the time that is most important to the healing process.
Cosmetic Property:Epilobium Angustifolium Extract is commonly known as Willowherb Extract,this extract is extracted from the Flower Leaf Stem part of this plant,and it got named as canadian willow herb in north america,general property of this extracts effective against acne bacteria, anti-inflammatory, anti-irritant, antioxidant, anti-microbial, anti-viral, cleansing. Acts as a natural analgesic, mimics hydrocortisone to sooth discomfort.
Thus this ingredient is excellent for traumatized skin whether by injury or cosmetic medical procedures.Epilobium augustifolium (Rose Bay Willow-herb), contains a bioactive molecule: Oenothein-B, patented for its wide ranging anti-inflammatory, non-steroidal activity. Its antiviral, anti-tumor and free radical scavenging abilities soothe inflamed or irritated skin while allowing healing to take place. The potent bioactivity makes it a therapeutic product recommended for irritated, red skin. Research performed in North America and Europe has found it outperforms 1% hydrocortisone in results measured: _ hour, 1 hour, 4 hours, and 24 hours. The Willowherb lotion was especially effective during the first three measured points of the test, the time that is most important to the healing process. Thus this ingredient is excellent for traumatized skin whether by injury or cosmetic medical procedures.
Since time immemorial, the peoples of the forest regions have used the juices of Willowherb(Epilobium angustifolium) as skin cleansers, fresheners and soothers for irritated areas of the skin. There are abundant ethnobotanical anecdotes concerning the beneficial effects of this substance on irritated skin. Contrary to what the name might imply, Willowherb is a non-willow plant that "soothes the forest" by quickly reclaiming areas scorched by forest fires. Ethnobotanical reports reveal that traditional healers used extracts of this plant to "soothe the human forest" as well. Clinical research has recently verified these reports further characterizing the potent non-steroidal anti-inflammatory activity of this extract and its component.
The principle bioactive molecule found in Willowherb extract is Oenothein-B. This molecule has been patented for its wide ranging bioactivity including anti-viral, antitumour, and anti-hyperandrogenic applications and also has demonstrated free radical scavenging ability.Willowherb has also been shown to effectively kill the P. Acne bacterium associated with acne.
The potent and wide ranging bioactivity of our Willowherb make them a vital component of almost any natural therapeutic product. Willowherb extracts provide safe, natural plant-derived functionality as strong as that of the best over-the-counter anti-irritants and anti-inflammatory products available. Action is exceptionally fast and the extracts are highly potent, so that high-efficiency formulated products are readily obtainable even with low levels of ingredient.
Oenothein B and Skin care case:Patent Application: CA 2386648
The invention provides compositions and methods for the prophylactic or therapeutic treatment of a skin condition involving Propionibacterium aches comprising an extract of Epilobium angustifolium (Rose Bay Willow-herb) or an oenothein selected from the group consisting of oenothein A, oenothein B,or tautomers,isomers,or derivatives thereof,any pharmacologically acceptable salts thereof,and/or a mixture of three tannins characterised respectively by high performance liquid chromatography. The oenothein for use in such compositions, such as oenothein A or oenothein B, and the mixture of three tannins may be purified from natural sources, such as plant material (e.g. Epilobium angustifolium).
Mechanism of Willow Herb.
All willow herb species contain flavorglycosides,especially derivatives of kaempferol,quercetin,and myricetin.Epilobium parviflorum also contains b-sitosterol, various esters of sitosterol,and sitosterol glucoside have been detected.These are the compounds considered to be the active ingredients of Saw Palmetto, another major herb used for treating the prostate.Gallic-acid derivatives are also present.Gallic acid and ellagitannins are considered to be the actives associated with the drinking of green tea.Two of these macrocyclic ellagitannins,oenothein A and oenothein B, have been identified as the main constituents responsible for the inhibition of 5-alpha-reductase and aromatese anzymes.These enzymes are considered to play key roles in the cancer of the prostate.
In summary, Small Flowered Willow Herb actives keep the prostate cells in their normal, differentiated state, allowing them to be the cells they were intended to be. Without exposure to these actives the cells can become clonal, leading to hyperplasia and cancer.
- 1.Wonderful uses of Willow Herb Species and Epilobium Class,willow herb extract from Epilobium parviflorum and Epilobium angustifollum.
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