Ecdysterone:20-hydroxyecdysone.:Introduction and Its Benefit Applications.
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Introduction:Ecdysterone.:
20-Hydroxyecdysone (ecdysterone or 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods. It is therefore one of the most common moulting hormones in insects, crabs, etc. It is also a phytoecdysteroid produced by various plants, including Cyanotis vaga, where its purpose is presumably to disrupt the development and reproduction of insect pests. In arthropods, 20E acts through the ecdysone receptor. Although mammals lack this receptor, 20E does appear to affect mammalian (including human) physiology, but there is disagreement over the details of its effects. 20E is an ingredient of some preparations that aim to enhance physical performance.
20-hydroxyecdysone (ecdysterone or 20-E) is a naturally occurring ecdysteroid hormone produced by various plants including Cyanotis vaga. Upon its isolation, it quickly became apparent that it was taken up by insects feeding on the plant, and played a key role in cell proliferation, growth and apoptosis by controlling gene expression involved in ecdysis and metamorphosis. It is one of the most common moulting hormones in insects, crabs, and some worms and can disrupt their moulting and reproduction. It has been suggested as a disruptor to avian influenza which can be transmitted through such vectors. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP) to cause a positive nitrogen balance in the body.
When first isolated, there was little interest from the commercial sector due to the lack of a cost-effective way to extract or synthesize the chemical. However, recent breakthroughs have meant that it can now be isolated in an extremely concentrated form. This has led to experimentation with its use as an anabolic steroid in sport and bodybuilding.
Despite lacking FDA approval and being largely illegal in the West, it has proven to be moderately successful as a commercial product in the countries in which it is produced, likely due to its efficacy in promoting muscle growth and fat loss, and lower frequency of side-effects usually associated with anabolic steroids. Such side effects are still fairly common, however, as a result of increased testosterone and DHT production, and include androgenic changes in females such as growth of facial and body hair and deepening of the voice, as well as gastrointestinal problems for both sexes, such as nausea, bloating, and diarrhoea. Clinical studies by ICN Pharmaceuticals demonstrated that the results are further improved when the drug is combined with a high-protein diet, to the point of equaling or even surpassing the beneficial effects of conventionally derived steroids such as Dianabol. The same studies showed the effective dose for a human to be around 5 mg per kg of body mass, daily. The compound becomes toxic only at doses of 6400 mg per kg of body mass per day.
Reference:
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- 1.Ecdysterone:20-hydroxyecdysone.:Introduction and Its Benefit Applications.
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♣ last edit date:28th,Oct.2010.
