What is Modified Citrus Pectin,MCP,an inhibitor of cancer metastasis and its wide uses?

Clinical Indications of MCP(Modified Citrus Pectin).:

Modified Citrus Pectin MCP photo picture image Prostate Cancer:

Pienta et al examined modified citrus pectin's effectiveness against prostate cancer metastasis in the Dunning rat model. Rats were injected with prostate adenocarcinoma cell lines and given drinking water containing various MCP concentrations. Oral MCP did not affect primary tumor growth, but significantly reduced metastases when compared to control animals. In one human study, Strum et al examined the effect of MCP on prostate specific antigen (PSA) doubling time in seven prostate cancer patients. PSA is an enzymatic tumor marker, and its doubling time reflects the speed at which the cancer is growing. Modified citrus pectin was administered orally at a dosage of 15 grams per day in three divided doses. Four of seven patients exhibited more than 30-percent lengthening of PSA doubling time. Lengthening of the doubling time represents a decrease in the cancer growth rate.

Breast Cancer:

As with prostate adenocarcinoma, research demonstrates metastasis of breast cancer cell lines requires aggregation and adhesion of the cancerous cells to tissue endothelium in order for it to invade neighboring tissue. The anti-adhesive properties of modified citrus pectin were studied in an in vitro model utilizing breast carcinoma cell lines MCF-7 and T-47D. MCP blocked the adhesion of malignant cells to blood vessel endothelia, thus inhibiting metastasis. A more recent human study examined galectin expression in 27 patients with invasive breast cancer. The study revealed that increasing histologic grades of breast cancer exhibited a decrease in galectin-3 expression, possibly resulting in increased cancer cell motility and metastasis.

Melanoma:

One of the better animal models for studying metastasis is the highly metastatic mouse B16-F1 melanoma. Using this system Platt and Raz determined that MCP significantly decreased tumor metastasis to the lung by more than 90 percent. In comparison, regular citrus pectin administration resulted in a significant increase (up to three-fold) in tumor metastases. The researchers concluded MCP's interference in the metastatic process might lead to a reduced ability to form tumor cell aggregates and metastases.

Reference:

1.What is Modified Citrus Pectin,MCP,an inhibitor of cancer metastasis and its wide uses?

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♣ last edit date:20th,Oct.2010.