Petasites hybridus,butterbur root,from tradition to modern uses.
- Botanical Data Info of Butterbur Root.
- Petasites hybridus: Introduction.
- Phytochemicals and Constituents.
- Mechanisms of Action.
- Migraine Traditional Treatment and Herbal Substitution.
- Medical uses for Petasites.
- Suggestions and Administrations.
- Petasites research petasites for migraine petasites.
- Petasites Research Update.
Phytochemicals and Constituents.:
Extracts of Petasites hybridus are prepared from the rhizomes, roots, and leaves.
The main active constituents are two sesquiterpenes, petasin and isopetasin. Petasin is responsible for the antispasmodic properties of the plant by reducing spasms in smooth muscle and vascular walls, in addition to providing an anti-inflammatory effect by inhibiting leukotriene synthesis. Prostaglandins are important mediators in the inflammatory process and isopetasin's positive impact on prostaglandin metabolism contributes to the effectiveness of Petasites extracts. Extracts of the plant also contain volatile oils, flavonoids, tannins, and pyrrolizidine alkaloids. As these alkaloids are believed to be toxic to the liver and carcinogenic in animals, extracts are available in which the pyrrolizidine alkaloids have been removed.
Effective content: tussilagone,C23H34O5; rutin,C27H30O16,0.36%; hyperoside,C21H20O12,0.28%.
The main active ingredients of petasites hybridus are two sesquiterpenes, petasin and isopetasin. Research has shown that petasin possesses anti-spasmodic properties that help to reduce spasms in smooth muscle and vascular walls. Petasin has also been found to be a powerful anti-inflammatory agent that inhibits synthesis of leukotrienes that act as potent pro-inflammatory agents in blood vessel walls, causing bronchoconstriction in asthma.The second active ingredient, isopetasin, has also been found to reduce inflammation by modulating prostaglandin metabolism. Together these ingredients have an antispasmodic effect on vascular walls, with a marked affinity for cerebral blood vessels.
- 1.Petasites hybridus,butterbur root,from tradition to modern uses.
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