Terminalia Belerica and Extract:General Information,Phytochemicals,History,Remedies and Uses Guide.
Contents
Modern Medical research.:
In addition, to having laxative and astringent properties, recent scientific studies have shown Terminalia Belerica to be a powerful adaptogen. An adaptogen is a hypothetical treatment or prescription for health. A healthy lifestyle is the one indisputable example of an adaptogen. Eating right, exercising, and doing all things in moderation will help the body adapt to stresses such as heat, cold, exertion, trauma, sleep deprivation, toxic exposure, radiation, infection, or psychological stress. There are no side effects with an adaptogen. It must be able to treat a variety of illnesses and help an organism return to its balanced state no matter what the cause. Further scientific studies have shown that Terminalia Belerica lowers lipid levels in the liver and heart, and works well in preventing heart and liver fat congestion, which lowers the risk of disease associated with those organs. Preliminary studies have shown its effectiveness in inhibiting viral growth in leukemia patients, and other studies are showing promise in Terminalia Belerica's ability to hinder the spread of the HIV virus.
AIDS: An extract of Terminalia bellerica showed significant inhibitory activity on human immunodeficiency virus-1 reverse transcriptase, with IC50 NMT 50 micrograms/ml (el-Mekkawy et al 1995). Four lignans (termilignan, thannilignan, hydroxy-3',4'-(methylenedioxy) flavan, anolignan B) possessed demonstrable anti-HIV-1 in vitro (Valsaraj et al 1997).
Antimalarial: Four lignans (termilignan, thannilignan, hydroxy-3',4'-[methylenedioxy] flavan, and anolignan B) possessed demonstrable antimalarial activity in vitro (Valsaraj et al 1997).
Antimutagenic: Two polyphenolic fractions isolated from T. bellerica were significantly effective against mutagenic effects in Salmonella typhimurium. Interaction of the polyphenols with S9 proteins may be the probable cause of the inhibitory effect (Padam et al 1996).
Antifungal: Four lignans (termilignan, thannilignan, hydroxy-3',4'-[methylenedioxy] flavan, and anolignan B) possessed demonstrable antifungal activity in vitro (Valsaraj et al 1997).
Antioxidant: Terminalia chebula Rotz extracts could be applied reducing free radical in cigarette smoke,this products releases antioxidant and good for fighting with free radicals inside your body.
Comments: Vibhitaka is a stimulating astringent, and has a wide application in any condition of atony, prolapse, and relaxation of the mucosa. For coughs, sore throats, laryngitis and dyspepsia the churna may be taken with honey. In the treatment of dry, irritative coughs Nadkarni recommends a linctus of equal parts Vibhitaka, Saindhava (rock salt), Pippali (Piper longum), and Maricha (Piper nigrum) (1976, 1204).
Frawley and Lad mention that Vibhitaka is useful in the treatment of cholelithiasis and urinary lithiasis, liquefying and expelling the stones (1986, 164). It is useful in the treatment uterine and colonic prolapse, and hemorrhage (Varier 1996, 258). The mature, dried fruit of Vibhitaka is effective in the treatment of diarrhea, dysentery and parasites, but in the latter case should be taken along with purgatives such as Senna (Cassia angustifolia) as Vibhitaka can be constipate (Varier 1996, 258). A decoction of the fruit may be taken internally and can be used externally as an eyewash in the treatment of ophthalmological disorders (Nadkarni 1976, 1204). Vaidya Mana Bhajracharya indicates that the fresh fruit pulp is used as a collyrium in the treatment of nontraumatic corneal ulcer (avranashukla) (1997, 85). Varier mentions that the oil from the seeds is trichogenous, and can be used topically for leucoderma and skin diseases (1996, 258). Vibhitaka is most commonly found as an ingredient in Triphala, usually mixed in equal parts with Haritaki and Amalaki.
Interaction between Ellagic Acid and DNA:
Some Scientists found that the interaction between ellagic acid and DNA has been characterized with respect to the geometry of the ellagic acid-DNA complex, and the active form of ellagic acid has been identified. Optical spectroscopic methods have been employed to examine the interaction between double stranded calf thymus DNA and ellagic acid in low ionic strength aqueous solutions at pH values of 5.5, 7.0 and 8.8. Based on normal absorption titration and flow linear dichroism experiments, it is confirmed that the neutral form of ellagic acid present at pH 5.5 binds to double stranded DNA. It is found that the plane of the ellagic acid chromophore is positioned at an angle relative to the DNA helix axis, which is in accordance with intercalation of ellagic acid in DNA. It is concluded that at higher values of pH no or a very limited amount of ellagic acid binds to DNA. These results prove that the direct interaction between ellagic acid and DNA must be taken into account when evaluating the mechanism underlying the observed biological effects of this plant phenol.
Antimalarial, and antifungal activety:
A bioactivity-guided fractionation of an extract of Terminalia bellerica fruit rind led to the isolation of two new lignans named termilignan and thannilignan, together with 7-hydroxy-3', 4' -(methylenedioxy)flavan and anolignan B. All four compounds possessed demonstrable antimalarial,and antifungal activity in vitro.
Reference:
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- 1.Terminalia Belerica and Extract:General Information,Phytochemicals,History,Remedies and Uses Guide.
This article written and edited via herbalist of MDidea Extracts Professional. They run a range of online descriptions about this herb,including general information related and summarized updating discoveries from findings of professional scientisits this field related.Describe style aimed to form a useful detecting literature space where the intertwined threshold and related questions raise out and visualize themselves.
♣ last edit date:22nd,Oct.2010.
