What is Rubia cordifolia and Rubia Root?Characters,Phytochemicals and Applications.

Contents

• Botanical Info of Rubia cordifolia and Rubia Root.
• Rubia cordifolia Plant Descriptions and Source.
• Characters and Identification:Rubia cordifolia Root.
• Rubia Root Constituents and Phytochemicals.
• Archeology and Classical Note:Rubia Root.
• Pharmacological Study:Rubia root and extract.
• Rubia Root Toxicity and Safety Info.
• Functions and Applications Guide of Rubia Root.
• Rubia Root Clinical Applications and Report.
• Research Update:Rubia Root.

Pharmacological Study:Rubia root and extract.:

1. Hemostatic effects:

 Carbon rubia root oral mouse shorten the tail bleeding time.rubia root extract saps can slightly reduce rabbit blood clotting time,prove hemostatic effects.

 Rabbits oral proper rubia extract 2-4 hours, or intraperitoneal injection of the same dose of rubia extract 30-60 minutes obviously promoting blood coagulation. Calcium time, prothrombin time and white pottery on the activated partial thromboplastin time be shortened. Rubia carbon can be significantly reduced oral mouse tail bleeding time. Rubia root also obviously correct coagulation disorder caused by the heparin. Rabbits oral warm extract, can be partially corrected in the body of heparin-induced calcium white clay time and activated partial thromboplastin time extension. Normal rabbit serum calcium white clay time and activated partial thromboplastin time was 110 seconds, 45 seconds, only 60 minutes after the injection of heparin more than 600 seconds; reperfusion rubia warm extract (100% 50 ml) after 90 mm, again 60 minutes after the injection of heparin for 64 seconds and 180 seconds. To this end, Rubiaceae can be used for the treatment of heparin, or heparin-like substance caused by excessive bleeding disorders. Experimental study and prove rubia and fish sperm protein. Toluidine blue were anti-heparin, and then there are correct Salvia role of anticoagulation. Fish sperm protein, toluidine blue Salvia and rubia on the role of anticoagulation orange-Results: normal thrombin clotting time of 9.5 seconds, 12.5% of the plasma Salvia 50.8 seconds, 1% of protamine shortened 34.8 seconds, and rubia extended 1.2 seconds. Tip of the Rubiaceae Procoagulant role are unique.

 2. Anti-platelet aggregation:

 In the test tube, the large leaf rubia shows strong inhibition on arachidonic acid (AA) and collagen-induced platelet aggregation of rabbits, IC50about 86.6 mmol / L, also shows certain extent of inhibition on platelet activation factor (PAF) induced aggregation. 2-methyl-1,3,6-trithydroxy-9,10-anthra quinone shows strong inhibition on collagen induced platelet aggregation,weaker inhibition on thrombin,AA and PAF induced, but there is still significant.


 3. Leukogenic effect:

 Rubia root extract has leukogenic effect. Its leukogenic effects brings by phenol carboxylic acid glycosides with aromatic rings, the active rubidate synthetic available. rubidate elevated the white blood cells of mice and rat,mice: oral administration of 2.5 mg, and 8 hours after administration interleukin increased significantly,for the treatment group 151.9% of the control group (P less than 0.05). . Dog oral 200 mg one time,interleukin significantly increased in six hours,18-24 hours of peak ,48-72 hours before gradually restored to the level of administration. Rubidate also promote mouse bone marrow hematopoietic stem cell proliferation and differentiation of control induced by cyclophosphamide dog leukopenia.

 Ruberythric acid I and Ruberythric acid II proved increase the leukocyte. Clinical use of rubia root decoction liquor extract for treatment of cancer chemotherapy and radiotherapy patients leukocyte reduction and unexplained leukopenia have received some results.
 

 4.Antitussive and sputum effect:

 Ammonia spray primer cough law and excretion of phenol red method proved mice oral rubia root decoction 75 g/kg, with a clear expectorant and antitussive effect, but the increase ethanol precipitation filtrate would be invalid. Effect of oral rubia root of mice significantly inhibit cough, expectorant(ammonia spray primer cough). Clinical compatibility with hesperidin for the treatment of chronic bronchitis received some results.

 5.In vitro inhibitory effect:

 In vitro experiments show that,rubia root hydrolic extract shows inhibition on Staphylococcus aureus,Streptococcus pneumoniae, Bacillus influenza and some skin fungi. Rubia root in the test tube shows certain inhibition effects on the yellow and white Staphylococcus aureus,catarrhalis, influenza and pneumococcal bacteria have some effect.


 6.Anticarcinogenic effect:

 Rubia root contained cyclohexyl peptide compounds RA (rubiaakane) -V10mg/kg,RA-VII 4mg/kg intraperitoneally five consecutive days, P388 lymphoblastic leukemia in mice were significantly treated. RA-V shows active effects on mouse lymphoid leukemia L1210, MM2 breast cancer; RA-VII shows inhibitive effects on mouse L1210, B16 melanoma, colon adenocarcinoma Colon38, Lewis lung cancer, Ehrlich carcinoma. Test showed that tumors in mice inhibited by activity of a component named RC-18, could significantly prolong the P388, L1210 and B16 mice life, but no obvious effect on Lewis lung cancer and sarcoma S180. RC-18 spectrum of anti-tumor results suggest that, the RC-18 may be developed into an effective Anti-Cancer medicine. In addition, 2 - methoxy-carbon -3 - isoamyl ene-2 ,3 - COX-1 ,4 Naphthoquinone in vitro experiments, the hamster lung (V79) cells, lymphatic leukemia (P388), and nasopharyngeal carcinoma cells (KB) proved its antitumor activity. Overall test S180 of mouse ascites effective.

 7.Urinary calculi effect:

 20% rubia agents feeding mice to prevent experimental kidney and bladder stone formation, in particular the formation of calcium carbonate stones inhibition. Madder root extract administered to rat urine can significantly improve stability and reduce the risk of urinary stone formation, and there is a certain role in reducing urinary calcium. rubia agents extra treatment of bladder stones, or its magnesium ammonium form from the stone a certain solvents, but the bladder stones actually have little effect, it may be excited bladder muscles, which will help remove the stones, in rats kidney or bladder stone formation, but also inhibit or prevent certain role.

 8.Myocardial infarction treatment:

 Sustainability of the ligation of left anterior descending coronary artery, causing artificial myocardial infarction model, intravenous use different methods of separation rubia root extract I,rubia root extract II 200 mg/kg every 4 hours,total three times, have reduced ST and the elevation of the narrow scope of the role of myocardial infarction. Rubia II the most obvious.Rubia root extract water-soluble part can significantly increase mice cardiac and brain tissue contents of ATP, ADP induced platelet aggregation broken rats Poly role. For narcotic large acute myocardial ischemia has a protective effect, reducing the scope of myocardial injury, damage mitigation, can increase coronary flow.

 9.Effect on smooth muscle:

 Rubia root decoction can release spasm effect on isolated rabbit intestinal cramps induced by confrontation acetylcholine,Rubia root hydrolic extract shows exciting effect on isolated guinea pig uterus.

 10.Other effects:

 Rubia root extract release effect of expansion frog vascular role.rubia root plays similar as Rutin, can inhibit the permeability of connective tissue in skin.

Reference:

• 1.What is Rubia cordifolia and Rubia Root?Characters,Phytochemicals and Applications.

This article written and edited via herbalist of MDidea Extracts Professional. They run a range of online descriptions about this herb,including general information related and summarized updating discoveries from findings of professional scientisits this field related.Describe style aimed to form a useful detecting literature space where the intertwined threshold and related questions raise out and visualize themselves.

♣ last edit date:27th,Oct.2010.