Angelica dahurica is a perennial herb,Bai Zhi is the root of Angelica dahurica Fisch. ex Hoffm. Benth. et Hook.f.

Contents

• Basic Botanical Info:Angelica dahurica.
• Botanical Descriptions:Bai Zhi.
• Angelica dahurica Characters and Identifications.
• Preparation Methods of Angelica dahurica.
• Angelica dahurica Constituents and Phytochemicals.
• Archeology and Classical Note:Angelica dahurica.
• Angelica dahurica Pharmacological Study.
• Toxicity and Safety Study:Angelica dahurica.
• Angelica dahurica Administrations and Applications.
• Research Update:Angelica dahurica.

Angelica dahurica Pharmacological Study.:

1. Anti-inflammatory effect: Mice gavage Baizhi or Hang Baizhi decoction (1 grams decoction equal to 1 grams crude herb) 4g/kg, could significantly inhibit xylene induced ear inflammation (P less than 0.01).

 2. Antipyretic and analgesic effects: animal model rabbits high fever caused by peptone subcutaneously in the back, 1 gram Baizhi decoction or Hang Baizhi decoction 15 g/kg, with a clear and antipyretic effects. Mice gavage Baizhi or Hang Baizhi decoction of 8 g / kg,intraperitoneal injection of 1% acetic acid (0.1 g/ kg) induced by significantly reducing the number of writhing, and the effects similar as Amidazophen 8 mg/kg, P less than 0.001. Mice hot plate test, the pain threshold before delivery in 30 minutes or less, or gavage to the Baizhi Hang or Baizhi 8g / kg, 60 minutes after administration,the pain threshold was significantly improved, and saline group, P less than 0.001 and 0.01.

 3. Spasm effect: This herb contains bergaptene, 8-Methoxypsoralen, isoimperatorin B,these components shows obvious spasm effects on rabbit ileum. Isoimperatorin can increase the rabbits palais contractility and the tension of earthworms muscle. Scopoletin shows spasm effects in vivo or in vitro rat uterine cramps induced byestrogen or barium chloride, its ED50 value 0.09mg/kg.

 4. Cardiovascular effects: This herb contains isoimperatorin and Marmesin lowering blood pressure of cats, 50 mg/kg decreased arterial blood pressure 50% of 1.5 hours time. Isoimperatorin and N-vinyl pyrrolidone copolymer can extend the cat blood pressure period length of 5-10 times,heart contraction of isolated Frog reduced.

 5. Antibacterial effect: Baizhi decoction shows inhibition effects on E. coli, Shigella, Proteus, Salmonella typhi and paratyphoid bacteria, Pseudomonas aeruginosa, Vibrio cholerae,Mycobacterium tuberculosis. The materials contained oxygen imperatorin shows antibacterial activity in vitro test for 11 strains; isoimperatorin in some antibacterial effect,Methoxsalen shows inhibition on mycobecterium tuberculosis H37RV the MIC was 100 mcg/ ml, respectively. Decoction shows certain inhibition effects on pathogenic fungi spores Trichophyton.


 6. Photosensitive role: This herb contains Bergapten, Methoxsalen, isoimperatorin B and other furan-coumarin compounds for the active substances when they enter the body,once sunlight or ultraviolet radiation, the skin can occur by exposure to solar dermatitis, a red, pigmentation, such as thickening of skin. Photosensitive activity to Methoxsalen is the strongest, followed by Bergapten, isoimperatorin B weaker. Photosensitive substances can be used to the treatment of vitiligo. Isoimperatorin effective for the treatment of psoriasis ingredients, clinical use of erythema determination proved to be effective.

 7. Anticarcinogenic effect: isoimperatorin and byak-angelicin with the Hela cell cytotoxicity. Isoimperatorin the ED50 100 ug/ml, respectively.
 

 8. Anti-radiation: Baizhi methanol extract 1g/kg in the X-ray irradiation five minutes before the intraperitoneal injection of mouse skin damage protective effect.

 9. Other effects: a small amount of bai zhi shows exciting effects on animals medullary vasomotor center, respiratory center, the vagus nerve and spinal cord,enabling a rise in blood pressure, pulse rate slows down, breathing deepened, and can cause drooling vomiting, and can lead to the use of intermittent cramps, followed by general paralysis.

Reference:

• 1.Angelica dahurica is a perennial herb,Bai Zhi is the root of Angelica dahurica Fisch. ex Hoffm. Benth. et Hook.f.

This article written and edited via herbalist of MDidea Extracts Professional. They run a range of online descriptions about this herb,including general information related and summarized updating discoveries from findings of professional scientisits this field related.Describe style aimed to form a useful detecting literature space where the intertwined threshold and related questions raise out and visualize themselves.

♣ last edit date:27th,Oct.2010.