Lobelia Herb and Its applications,effects and cautions.

Pharmacological Effects of Lobelia Herb.:

Lobelia Herb Extract Lobelia chinensis Lour ext Chinese Lobelia Herb Campanulaceae plant Lobelia chinensis Lour photo picture image 1. Diuretic effect:

Anesthetized dogs iv Lobelia Herb decoction saps 0.1 g/kg, or Lobelia Herb total alkaloids 6.6 mg/kg, normal rat 1g/kg, as well as normal person Lobelia Herb powder 10-30 g, notable and lasting diuretic effect proved, chloride in urine excretion also significantly increased. inulin isolated from Lobelia Herb suppress the diuretic effect.

2. Nervous system effect:

Lobelia Herb effects on the nervous system similar to nicotine, but strength only 1/5-1/20 of nicotine,the autonomic Festival, adrenal medulla, the extension of the central brain (especially vomiting center), a nerve junctions, as well as aortic and carotid body chemoreceptor all of the first exciting then suppression effects.

3. Central system inhibition:

Lobelia Herb contain succinic acid on mice, rats, guinea pigs, rabbits, cats and dogs administration can protect animals against hyperbaric oxygen, electric shock and listen endogenous convulsion. Hot plate method proved its analgesic effects, and synergies with pentobarbital sodium,sedative and reduce the body temperature.

4. Respiratory exciting role:

Lobelia Herb decoction and Lobelia Herb alkaloid formulations iv shows significant respiratory exciting effects on dogs. With its effects strengthening and increasing when dose added up.Over dose can cause excessive respiratory paralysis and death. Sinus nerve resection or removal of carotid body, and then injected Lobelia Herb agents not apparent respiratory exciting. That its effect is mainly through the mechanism of stimulation of carotid body chemoreceptor reflex and excited respiratory center. Lobelia Herb better exciting morphine-induced respiratory depression, and poor to the depression induced by Wulatan Chloral Hydrate.Lobelia Herb alkali inhalation, expansionist bronchial to combat tracheal contraction induced by hair pilocarpine alkali and acetylcholine .

5. Role in the cardiovascular system:

Lobelia Herb decoction iv,shows significant and long-lasting relief effect on narcotic dogs. If duodenal administration will need 10 to 20 times the amount of intravenous dose.Lobelia Herb decoction Iv also reported a small vlome of short-term boost effect and a larger dose brings more lasting relief effect. Lobelia Herb alkaloid shows exciting effect on isolated rabbit hearts and frog hearts to strengthen the contraction and amplitude increased when a high concentration, followed by inhibition, in the last block and cardioplegia. Lobelia Herb alkaloid Im, in the excitement at the same time breathing, heart rate slower, blood pressure increased when large dose accelerated heart rate, blood pressure decreased significantly, and finally to the heart paralysis.

6. Choleretic effect:

Dog iv taken Lobelia Herb water alcohol preparations 1 g (raw herb)/kg, bile flow increase more than two times before administration, and reach peak in 50 minutes after administration, but bile solids, bile salt and red bile the concentration of both lower.

7. Anti-snake venom effect:

Lobelia Herb agents, as well as separated sodium succinate,sodium fumarate,Sodium p-hydroxybenzoate po 30 minutes before injection of venom,or sc same time injection venom, or sodium succinate,sodium fumarate and sodium acetate combined as formulas -4hpo 30 minutes before injection of venom, for the smallest full-lethally injected cobra venom in mice have a higher protective effect, the protection rate of 59.1-93.1%. But in the 25 minutes after the injection of venom delivery again, no protective effect.

8. Other effect:

8.1. Antiulcer effect: Lobelia Herb contained Succinic acid 50 mg/kg, to combat the ligation rats pyloric ulcer is the result of gastric secretion and inhibit expansion stomach muscle and anti-ulcer effect. Cats and dogs im Lobelia Herb alkaloids vomit.

8.2. Light diarrhoea effect: Lobelia Herb decoction po light diarrhea, and can inhibit appetite.

8.3. Bacteria Inhibitory effect: In vitro experiments, Lobelia Herb decoction shows inhibition on common pathogenic fungi,Staphylococcus aureus and Escherichia coli.

8.4. Hemostasis Effect: Lobelia Herb Ip delivery can shortened mice tail cut bleeding time.

8.5. Anticarcinogenic effect: Lobelia Herb alkaloids 15 mcg/ml, mouse ascites carcinoma cells uptake of oxygen inhibited.

Reference:

1.Lobelia Herb and Its applications,effects and cautions.

This article written and edited via herbalist of MDidea Extracts Professional. They run a range of online descriptions about this herb,including general information related and summarized updating discoveries from findings of professional scientisits this field related.Describe style aimed to form a useful detecting literature space where the intertwined threshold and related questions raise out and visualize themselves.

♣ last edit date:27th,Oct.2010.