Research Summary of Grape Seed Extract.


Research Summary of Grape Seed Extract.

Grape Seed Vitis vinifera Extract Oligomeric Proanthocyanidins OPC Polyphenols Antitumor-promoting activity, described as highly significant, has been observed in animals treated with topical grape seed proanthocyanidins. Skin tumor incidence, multiplicity and volume were all significantly inhibited. These effects were attributed to inhibition of epidermal lipid peroxidation. Higher doses resulted in greater degrees of cancer inhibition.

 An extract of grape seed proanthocyanidins has significantly inhibited human breast cancer, lung cancer and gastric adenocarcinoma cells in vitro. The extract did not inhibit neoplastic K562 myelogenous leukemic cells. In the same experiment, the extract enhanced growth and viability of normal human gastric mucosal cells and J774A.1 murine macrophage cells. These promising preliminary findings warrant more research.

 Grape seed proanthocyanidins have been shown to significantly inhibit the peroxidation of polyunsaturated fatty acids and some other lipids in animal and in vitro studies. Some experimental data suggest that these effects might help protect capillaries, heart, brain and liver tissues in some circumstances. In one study, a grape seed proanthocyanidin extract more potently protected brain and hepatic tissues from the damage of experimentally induced reactive oxygen species damage than did other antioxidants (vitamin C, vitamin E succinate and beta-carotene). In other in vitro experiments, grape seed proanthocyanidins have strongly inhibited reactive oxygen species activities implicated in microvascular injury.

 Acetaminophen-induced programmed and unprogrammed liver-cell death was dramatically prevented and reduced in mice treated with a grape seed proanthocyanidin extract. Exposure to the extract for seven days prior to acetaminophen administration was notably more effective than pre-treatment for three days. The extract significantly counteracted acetaminophen-promoted apoptotic DNA fragmentation.

 In another animal model, grape seed proanthocyanidins were shown to increase resistance to myocardial ischemia reperfusion injury. And in a recent experiment utilizing cholesterol-fed rabbits, an extract of grape seed proanthocyanidins significantly attenuated the development of aortic atherosclerosis compared with controls that did not receive the extract.


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Available Product
  • Name:Grape Seed Extract
  • Serie No:S-035.
  • Specifications:Oligomeric Proanthocyanidins.95%UV-VIS(OPC).Polyphenols.90%UV-VIS.
  • EINECS/ELINCS No.:284-511-6
  • CAS:84929-27-1
  • Chem/IUPAC Name:Vitis Vinifera Seed Extract is an extract of the seeds of the grape,Vitis vinifera,Vitaceae
  • Other Names:Red Wine Extract.Vitis Vinefera Seed Extract.Grape seed Proanthocyanidins.Oligomeric Proanthocyanidins.Procyanidins,Leucoanthocyanins,Pycnogenols.

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Grape Seed Extract INCI Name VITIS VINIFERA SEED EXTRACT EINECS ELINCS No 284-511-6 CAS 84929-27-1 Oligomeric Proanthocyanidins OPC Polyphenols

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