Milk Thistle:Silybum marianum,its botanical information,constituents,history,applications and administration guide.


Applications and Properties:


Milk Thistle Silybum MarianumInhibitor of Beta-glucuronidase.
Anti Free radicals.
Hepatoprotective,Liver injury protection of silymarin.
Silymarin reduced lipoperoxidative hepatic damage.
Silymarin proved against hepatotoxicity.
Promotes milk secretion,treat lactation problems,prevent cancer.


A number of studies have suggested that silymarin is an anti-inflammatory. It regulates inflammatory mediators such as tumor necrosis factor (TNF), TNF-alpha, nitrous oxide, interleukin-, and interleukin-1 receptor antagonist. Silymarin also increases lymphocyte proliferation, interferon gamma, interleukin-, and interleukin- cytokines, in a dose-dependent manner. Taken together, these effects suggest a possible role in preventing or treating infectious disease.

Dosage:"For liver dysfunction or ailments,the daily dosage has been effective and well tolerated at 140 to 420mgs divided in 2 to 3 doses(Ferenci,1989;Frerick,1990;Pares,1998;Schuppan,1998).The average dose of silymarin was approximately 33mg/kg/d for cyclopeptide mushroom poisoning.Silymarin administered up to 48 hours after mushroom ingestion appears to be effective in preventing severe liver damage in Amanita phalloides poisoning(Hruby,1983).Although products are usually standardized to 70% to 80%(not milligrams) of silymarin,the silymarin concentrations may vary without government regulation(Flora et al.1998)."

Safety and Toxicity:

Milk Thistle Silybum MarianumAcute toxicity(LD50):Silymarin.LD50-Lethal dose,50 percent kill.Intravenous.Rodent-mouse.>1600 mg/kg.Details of toxic effects not reported other than lethal dose value.

In clinical trials,milk thistle generally has few side effects.Occasionally, people report a laxative effect,upset stomach,diarrhea,and bloating.Milk thistle can produce allergic reactions,which tend to be more common among people who are allergic to plants in the same family (for example,ragweed,chrysanthemum, marigold,and daisy).It is important to inform your health care providers about any herb or dietary supplement you are using,including milk thistle.This helps to ensure safe and coordinated care.


  • Milk Thistle:Silybum marianum,its botanical information,constituents,history,applications and administration guide.
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♥The article and literature were edited by Herbalist of MDidea Extracts Professional.It runs a range of descriptions about the titled herb and related phytochemicals, including comprehensive information related, summarized updating discoveries from findings of herbalists and clinical scientists from this field.The electronic data information published at our official website and, we tried to update it to latest and exact as possible.
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Available Product
  • Name:Milk Thistle Extract
  • Serie No:S-017.
  • Specifications:Silymarin 80%UV(DAB10.USp32.Ep7.0)
  • EINECS/ELINCS No.:283-298-7
  • CAS:84604-20-6
  • Chem/IUPAC Name:Silybum Marianum Extract is an extract of the seeds and leaves of the lady's thistle,Silybum marianum,Compositae.
  • Other Names:Silybum marianum (L.) Gaertner Extract.Cardui Mariae Fructus Extract.St. Mary Thistle Seed,Carduus marianus syn. Silybum marianum,Cardui mariae fructus.

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Milk Thistle Extract.Silymarin.Silybum Marianum Extract.CAS 84604-20-6.EINECS ELINCS No 283-298-7

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