St.John's Wort:Phytochemicals and Common Uses.


St.John's Wort:Phytochemicals and Common Uses.

Phenolic compounds from Hypericum perforatum:

St Johns Wort Hypericum perforatum Herb Constituents: naphthodianthrones (including the red pigment hypericin, pseudohypericin and their biosynthetic precursors), flavones and flavonols (quercetin glycosides including quercitrin, rutin, quercetin, kaempferol, luteolin), carotenes, essential oil, resin, tannins, pectin

 During a re-investigation of phenolic compounds from the dried crude drug material of St. John's wort (Hypericum perforatum L.) 22 phenolic compounds were detected by HPLC; 14 of them were quantified using the same system. Twelve phenolic compounds were isolated from the plant material and their structures identified mainly by spectroscopic methods, among them quercetin-3-O-(2"-O-acetyl)-beta-D-galactoside as a new natural product. Cryptochlorogenic acid, protocatechuic acid, 3-O-[Z]-p-coumaroylquinic acid, isoorientin, cyanidin-3-O-alpha-L-rhamnoside, and astilbin were obtained for the first time from this source; the earlier suspected neochlorogenic acid, 3-O-[E]-p-coumaroylquinic acid, mangiferin, miquelianin and guaijaverin were confirmed.

Different group phytochemicals of St. John's Wort:

 St. John's Wort,Hypericum perforatum HerbThe Hypericum perforatum herb contains different groups of phytochemicals:

 Phenolic acids(chlorogenic acid,caffeic acid,p-coumaric acid,ferulic acid,p-hydroxybenzoic acid,vanillic acid,etc.)
 Tannins(unspecified,proanthocyanidins reported,etc.)
 Volatile oils(2-methyloctane,nonane,2-methyldecane,undecane,alpha-pinene,beta-pinene,alpha-terpineol,geraniol,myrcene,limonene,caryophyllene,humulene,etc.)
 Saturated fatty acids(isovaleric acid(3-methylbutanoic acid),myristic acid,palmitic acid,stearic acid,etc.)
 Vitamins and their analogues(carotenoids,choline,nicotinamide,nicotinic acid,etc.)
 Miscellaneous others(pectin,beta-sitosterol,hexadecane,triacontane,kielcorin,norathyriol,etc.)
 The naphthodianthrones hypericin and pseudohypericin along with the phloroglucinol derivative hyperforin are thought to be among the numerous active constituents.It also contains essential oils composed mainly of sesquiterpenes.

Medicinal Action and Uses of St. John's Wort:

 St.John's Wort,Hypericum perforatum HerbMedicinal Action and Uses:Aromatic, astringent, resolvent, expectorant and nervine. Used in all pulmonary complaints, bladder troubles, in suppression of urine, dysentery, worms, diarrhoea, hysteria and nervous depression, haemoptysis and other haemorrhages and jaundice. For children troubled with incontinence of urine at night an infusion or tea given before retiring will be found effectual; it is also useful in pulmonary consumption, chronic catarrh of the lungs, bowels or urinary passages. Externally for fomentations to dispel hard tumours, caked breasts, ecchymosis, etc.

 Collection:During the flowering period, from June to August. To make the macerated oil, pour half a litre of sunflower or almond oil onto 120g of flowers in a glass jar, then place in direct sunlight for about six weeks or longer until the liquid has turned bright red. Strain through muslin and decant off from any watery layer.

 Actions:Anxiolytic, sedative, astringent, anti-inflammatory, topically analgesic and antiseptic.

 Indications:Excitability, neuralgia, fibrositis, sciatica. Topically for wounds. Specifically indicated in menopausal neurosis.

 Therapeutics and Pharmacology:Hypericum has a thymoleptic action which results in an improved sense of well-being. It has long been used as a nerve healer in melancholic conditions, depression, exhaustion and convalescence. It is also used to treat conditions where there is a degree of overtension, such as insomnia, cramps and colic of the viscera and uterus, epilepsy, diarrhoea, and enuresis in children. Of the many conditions where nervous tension and depression occur together, one of the most common is the problems that can arise during menopause, and Hypericum helps to counter these symptoms. ESCOP recommends its use in mild to moderate depressive states (ICD-10, F32.0, F32.1). The flavonoid aglycones and quercitrin have an anxiolytic effect by inhibiting Type A monoamineoxidase (hypericin has a rather low activity). Both the restorative and relaxing actions of the herb are relatively long-term ones, so treatment should be continued for some time. Clinical trials have reported improved sleep quality, an increase in deep sleep phases, and an improvement in cognitive functions as well as significant improvement in mood and levels of interest and activity. In a preliminary study of a Hypericum preparation combined with light therapy in patients with seasonal affective disorders, the antidepressant effect of Hypericum was shown to be enhanced by light therapy.
 St Johns Wort Hypericum perforatum Herb Hypericum has a reputation as an analgesic, and is used either internally or externally to treat neuralgic pain. The macerated oil can be applied externally for neuralgia and will ease the pain of sciatica. It also soothes burns by lowering the temperature of the skin. Hypericum can also be used to treat local and peptic ulcers and inflammation of the lining of the upper digestive tract. Its astringent action is due primarily to the high levels of tannins in the flowers, and the volatile oil has an anti-inflammatory action. Hypericum has been shown to stimulate the formation of granulation tissue, and an antibacterial action, attributed to hyperforin, has been observed experimentally, particularly against Staphylococcus aureus. Some anti-viral activity has been reported for hypericin against the HIV and hepatitis C viruses.

 Caution:There is no evidence of toxicity at therapeutic doses. However, cattle and sheep can develop photosensitivity if they consume the plant in large quantities, and several HIV+ve patients on large doses of Hypericum have reported rash, pruritis and erythema after exposure to UV light. This is thought to be due to the presence of hypericin. Therefore, excessive exposure to bright sunlight should be avoided whilst taking the herb. If a significant response in depressive disorders is not apparent after 6 weeks, the use of Hypericum should be discontinued; however, the antidepressive effect should not be expected until at least two weeks of treatment.

 Though the net effect of taking St. John's wort and 5-HTP may be the same, if taken together SJW and 5-HTP are even more effective. St. John's wort is a SSRI, a Serotonin reuptake inhibitor, (Actually SJW inhibits the reuptake of all three feel-good neurotransmitters: serotonin, nor-epinephrine, and dopamine) but 5-HTP is a precursor to serotonin. What this means is that your body breaks 5-HTP down (in the neurons) into serotonin, the very chemical that St. John's wort manipulates to help you feel happier, calmer . . . The metaphor being; if you were an automobile you would be filling up your gas tank with 5-HTP, at which time the St. John's wort takes over, acting like a carburetor; instructing the serotonin where to (or in this case where not to) go. So, in essence, taking SJW and 5-HTP creates a synergy (1+1=3). Most studies were conducted using a dose of 50-100 mg. three times per day. Obesity patients 20 minutes before meals. The onset of action is fairly rapid, (3 to 5 days).

 St Johns Wort is known to have sedative and pain reducing effects. It is used to treat anxiety, tension and similar related problems. It is particularly useful duing menopausal changes such as irratibility and anxiety.

  St Johns Wort Hypericum perforatum Herb Hypericum Perforatum Extract is commonly known as St John's Wort Extract,it is known to have sedative and pain reducing effects. It is used to treat anxiety, tension and similar related problems. It is particularly useful duing menopausal changes such as irratibility and anxiety.St. John's wort contains several components that are toxic on skin in the presence of sunlight. St. John wort association with improving depression when taken as an oral supplement is unrelated to its topical impact on skin. However, it also has potent antioxidant properties.

 Blue Blend/Mood Uplifting:St Johns Wort may combined with Licorice works for taking durring the blues.This herbal combination has been developed to assist with the re-balancing of the nervous system and mood. St. John's Wort is known to have sedative effects. It is known for its mood uplifting properties.

Cosmetic uses of St John's Wort:

 St Johns Wort Hypericum perforatum Herb St. John's wort (Hypericum perforatum) is mostly known for its effect in lifting depression when taken orally, it also has some very positive effects on the skin when applied topically, and will help create an unblemished complexion.It contains phenolic compounds, terpenoids, hyperforin (a phloroglucinols derivative), hypericin (a dianthrone), naphtodianthrones, flavonoids, terpene and sesquiterpene oils, phenylpropanes, biflavones, tannins, xanthones, phloroglucinols, and essential oils.

 St. John's Wort (Hypericum Perforatum) Leaf has been traditionally used for centuries as a treatment for wounds and burns. Also used externally as an anti-inflammatory, astringent, and antiseptic.

 St Johns Wort Hypericum perforatum Herb Cosmetic uses of St. John’s Wort majorly focused on following aspects:This herb has great value in skin care, promoting healing and reducing inflammation. Although most people thought St. John's Wort as a treatment for sores and wounds was simply folklore, clinical trials showed that it not only helps wounds to heal better, but also has a great anti-inflammatory effect on the skin, helping to relieve skin inflammation. Other tests showed that it is of help with dermatitis while also showing anti-microbial properties.Although high oral dosage of St. John’s Wort may lead to photosensitivity – it was shown in clinical tests that very few people showed this effect when it is applied topically to the skin.


  • St.John's Wort:Hypericum perforatum herb,its introduction and constituents,its traditional use and as alternative therapy for depression.

♥The article and literature were edited by Herbalist of MDidea Extracts Professional.It runs a range of descriptions about the titled herb and related phytochemicals, including comprehensive information related, summarized updating discoveries from findings of herbalists and clinical scientists from this field.The electronic data information published at our official website and, we tried to update it to latest and exact as possible.
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  • Name:St.John's Wort Extract
  • Serie No:S-026.
  • Specifications:Hypericin 0.3%~0.4%UV.
  • EINECS/ELINCS No.:282-026-4
  • CAS:84082-80-4
  • Chem/IUPAC Name:Hypericum Perforatum Extract is an extract of the capsules,flowers,leaves and stem heads of the St. John's wort,Hypericum perforatum,Hypericaceae
  • Other Names:Common St.John's Wort,Amber,Chase-devil,Tupfelharthen,Mille Pertuis,Hierba de San Juan,Hypericum perforatum,H.perforatum,Perforata,Perforate St John's wort,Johnswort,Klamath weed,Hyperici herba,Tipton weed,Rosin rose,Guan Ye Lian Qiao.

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St. John's Wort Extract.INCI Name.HYPERICUM PERFORATUM EXTRACT,CAS.84082-80-4,EINECS ELINCS No282-026-4

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