Indications and Administration Guide of Zizyphus Seed:A liver-healthy anti-anxiety Herb.


Indications and Administration Guide of Zizyphus Seed:A liver-healthy anti-anxiety Herb.

Ziziphus spinosa Hu Semen Ziziphi Spinosae Jujube seeds are used for medicinal purpose. It is used as a remedy for irritability, insomnia, anxiety, oedema, congestive heart failure, asthma and throat diseases.

 Scientific studies with animals have shown Zizyphus jujuba seed to have anti-anxiety and hypnotic effects, causing a reduction in the speed of conditioned reflexes, a reduction in hyperactivity, and a lowering of blood pressure. Oral administration of the decoction of the herb prolonged sodium pentobarbital induced sleep in mice and significantly caused a subthreshold dose of sodium thiopental to induce anesthesia in rabbits. In human clinical studies, a significant tranquilizing effect of Zizyphus was found to measurably potentiate the concurrent administration of tranquilizing drugs.

 Other effects of Jujube seed augment its calming and sleep inducing effects, revealing potential for additional product applications. Because of its muscle relaxing effects, the herb is sometimes used as an anticonvulsant. Animal studies have demonstrated it effectiveness in reducing pain sensation and increasing pain tolerance, further substantiating its use as an analgesic. The herb could be useful in products for arthritis, backache, headache or any type of pain that interferes with sleep. In addition, for those with hypertension, Jujube seed has been shown to produce significant, persistent and prolonged reductions in blood pressure.

 Jujube General Information:

 Jujube has been a part of Chinese medicine for at least 2,500 years. The Chinese used it as a qi tonic to strengthen liver function. Jujube has a pleasant taste as well as a high nutritional value. The fruit contains vitamins A, B2, and C, and saponins, flavonoids, sugars, mucilage, calcium, phosphorus, and iron. Though the West had dismissed Jujube as having any medicinal qualities, since the 17th century, Europeans have recognized its usefulness as a tonic for all parts of the body, especially the lungs and kidneys.

 Jujube Uses and Scientific Evidence For:

 Today, depending on the culture, all parts of the tree are used. Pits that have been aged for 3 years can be used to treat wounds and abdominal pain; the leaves for typhoid fever and parasites in the intestinal tract. The heartwood is a powerful blood tonic; the Jujube root is used to promote hair growth and for treating fevers caused by smallpox, measles, and chickenpox. Jujube fruit is often prescribed for weight gain and increased muscular strength and stamina. The bark is used to make an eyewash for inflammations. A Jujube tonic is said to have positive effects when used in part of a treatment plan for hepatitis and cirrhosis, and tones the spleen and stomach. It has mildly sedative effects and can be taken for restlessness and irritability. Jujube fruit is used to treat coughs and congestion, soothe internal organs, and reduce water retention.

 Jujube Dosage Information:

 Jujube is an ingredient in many products. For best results, read and follow product label directions.

 Jujube Safety and Interaction Information:

 Jujube is general regarded as safe when taken in the recommended doses; however, using it to treat hepatitis and cirrhosis should only be done under the supervision of your physician. It is not meant to replace the quality healthcare a licensed physician can provide. Safety in young children, or pregnant or nursing women is not known.

 Indications and applications of Zizyphus:

 1. Irritability, dryness of eye, dizziness, insomnia and dreaminess due to deficiency of liver-yin , it is often used with Rhizoma anemarrhenae, Poria, Rhizoma ligustici, chuanxiong, and Radix glycyrrhizae to nourish the liver, calm heart and tranquilize the mind. For insomnia and amnesia due to deficiency of both Qi and blood and insufficient nourishing of heart and mind, this herb can be used with Radix ginseng. Radix angelicae sinensis, Arllus longan, Semen biotae, Poria, etc. to nourishing the heart to calm the mind, as in Ginseng Spleen Invigorating Bolus.

 2. For treatment of spontaneous sweating due to Qi-deficiency, and night sweat due to Yin-deficiency, this herb can be used with herbs of benefiniting vital energy and strengthening superfices and herbs of tonifying Yin and astringing sweat, to relieve primary and secondary symptoms at the same time.

 3. Nourishing the heart to tranquilize the mind, promoting generation of body fluid and arresting sweating.

 4. Nourishing liver and gall, pacifying nerve.

 Dosage and Administration: 10-15g, it can be ground into powder for an oral dose, 1.5-3.0g each time.

 Plus:Sleep Inducer (Zaoren Anshen Ye) is and old Chinese herbal sleep tonic that has been around for hundreds of years, and is one of the best and original oral liquids for the relief of insomnia and dream disturbed sleep.

 Ingredients: Zizyphus spinosa (Spine Date) seed, Schizandra chinensis fruit, Saliva miltiorrhiza root and rhizome. Contains fructose, sucrose and glucose from honey.

 A modern presentation of the formula is (4):

 Zizyphus (suanzaoren) 18 g
 Anemarrhena (zhimu) 10 g
 Hoelen (fuling) 10 g
 Cnidium (chuanxiong) 5 g
 Licorice (gancao) 3 g

 The actions of the formula, as described in the modern text, are to nourish the blood, clear heat, relieve restlessness, and treat insomnia. Anemarrhena is a cold-natured herb that contributes the action of clearing heat; as indicated in the Shennong Bencao Jing passage, zizyphus also contributes to clearing heat, even though it doesn't have a cold nature. Zizyphus provides all the other actions attributed to the formula. Its blood nourishing effect is complemented by that of cnidium, while both licorice and hoelen provide additional sedative effects and contribute to the overall tonification therapy by improving the spleen functions.

 In the context of analyzing Zizyphus Combination, one can mention the use of the related herb jujube in the well-known sedative formula Ganmai Dazao Tang (Wheat and Jujube Combination):

 Wheat (fuxiaomai) 15 g
 Jujube (dazao) 14 g
 Licorice (gancao) 9 g

 The dosage of jujube is usually measured by the number of fruits, in this case; the seeds are removed and the remaining fruit is about 2 grams. The actions of this small formula are to nourish the heart, normalize the function of stomach and spleen, calm the mind, and treat insomnia and spasms. The role of wheat, which is normally consumed by many people in large quantities (as in the form of noodles or bread), may be to treat B-vitamin deficiencies that can arise in people who do not normally eat wheat or other sources rich in these vitamins (B-vitamins play an important role in nervous system functions). This type of deficiency has been a common problem in the Orient. For example, in Java, until quite recently, beri beri (a Vitamin B1 deficiency that causes leg edema) was a common disorder because the diet lacked good sources of the vitamin, which is found in whole grains). The combination of jujube and licorice in this formula serves as a spleen tonic and sedative, which is a role similar to that of zizyphus and licorice in Zizyphus Combination.

 Generally Speaking, this herb is traditionally used for weakness, fatigue, debility, restlessness, hysteria and to assist in the actions of other herbs, as we believe it does in this formula. This herb contains vitamins A, B-2, C, calcium, phosphorus, iron and complex sugars. This herb is considered to nourish both the blood and the energy, which are mutually interdependent.

Administration Guide from different Pharmacopia reference:

 Indications and Dosage from CP for Zizyphus Seed:The CP noted the herb Zizyphus Seed taste sweet,sour,calm.Enter into the liver,bladder,heart meridians.Main function tonify liver,sedative heart,restrain sweat,generate saliva(promote the secretion of saliva or body fluid).Indicated for insomnia or sleepless due to anxiety and deficiency,palpitate with fear pavor and dreams,hyperhidrosis due to deficiency,body fluid impairment and thirsty.Suggested Dosage 9~15 grams.Store at cool dry place,prevent moths.

 Indications and Dosage from CHMM for Zizyphus Seed:The CHMM noted the herb Zizyphus Seed taste sweet and plain,enter into heart,spleen,liver,bladder meridians.Main functions sedative heart and calm mind,nourish liver,restrain sweat.Indicated for insomnia or sleepless due to anxiety and deficiency,palpitate with fear pavor and severe palpitation,spontaneous sweating due to deficiency,night sweat perspire during sleep.Suggested take internally as decoction 6~15 grams,or grained as powder 3~5grams each time,or prepare as pellet or powder.2

 Ziziphus spinosa Hu Semen Ziziphi Spinosae Precautions:

 1. Exercise caution when prescribing this formula to patients of excessive syndromes and patients of loose stool.
 2. Reported adverse effects include allergic reaction, fever with aversion to cold, joint pain, and cold sweat.

 Toxicity and Side Effects:

 Zizyphus is reported to have very low toxicity when taken orally. In laboratory animals (mice and rats), a huge single dose of 50 grams herb per kilogram of body weight produced no toxic symptoms, and a daily dose of 20 grams per kilogram for 30 days did not produce toxic reactions. Side effects are not reported. Modern pharmacology evaluation of zizyphus seed oil and zizyphus extract suggest that with prolonged feeding they can reduce serum triglycerides and cholesterol (mainly LDL), and reduce fatty degeneration of the liver. These properties have also been attributed to the triterpenes of ginseng and ganoderma.

 Acute Toxicity:

 Decoction.Oral.20 g daily.30 days.Calm and peace,average weight increase higher than comparative group,no big difference on appetite.
 Formula decoction.LD50.Lethal dose,50 npercent death.Mice.Peritoneal injection.: 14.3 +- 2.0 g/kg.
 Reference: Huang Hou Ping, et al. The tranquilizaing effect of Suan Zao Ren. Guizhou Journal of Medicine. 1982;(1):17.


 1: The Spine Date Seed or Chinese Sleeping Elixir,What is Semen Ziziphi Spinosa?
 2: see CHMM(Zhong Hua Ben Cao,or Chinese Herbal Materia Medica)

♥The article and literature were edited by Herbalist of MDidea Extracts Professional.It runs a range of descriptions about the titled herb and related phytochemicals, including comprehensive information related, summarized updating discoveries from findings of herbalists and clinical scientists from this field.The electronic data information published at our official website and, we tried to update it to latest and exact as possible.
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Available Product
  • Name:Semen Ziziphi Spinosae Extract
  • Serie No:R029.
  • Specifications:5:1.10:1,Jujuboside 1~2%HPLC
  • EINECS/ELINCS No.:289-966-4
  • CAS:90045-99-1
  • Chem/IUPAC Name:Zizyphus Jujuba Extract is an extract of the fruit of the jujube,Zizyphus jujuba,Rhamnaceae
  • Other Names:Spine Date Seed,Ziziphus spinosa Hu,Wild or Sping Jujuba Seed,Chinese Sleeping Elixir,Sour Jujube,Zizyphus Seed,Semen Ziziphi Spinosae,Zizyphus jujuba,Sour Jujuba Seed,Suan Zao Ren.

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Semen Ziziphi Spinosae Extract INCI Name Zizyphus Jujuba Extract CAS 90045-99-1 EINECS ELINCS No 289-966-4 Spine Date Seed jujuboside A jujuboside B betulinic acid

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