Xanthoparmelia Scabrosa:PDE-5 inhibitors and its Mechanism,How does the herb Xanthoparmelia work?

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Xanthoparmelia Scabrosa:PDE-5 inhibitors and its Mechanism,How does the herb Xanthoparmelia work?

Xanthoparmelia Scabrosa X-Scabrosa Natural Pyrazolo Pyrimidinone Xanthoparmelia Lichens The Xanthoparmelia Scabrosa plant contains substances that extend the duration of the erection. These substances delay the work of the PDE-5 enzymes so that the penis stays erect longer and delays the flaccid state.

 Xanthoparmelia Scabrosa naturally contains the substances 4-Methylpiperazine and Pyrazolo Pyrimidin-7-1.

 Xanthoparmelia Scabrosa as a lichen found in various parts of the world origins from China. Its active constituents Epiditiopiperazinedione/4-Methylipiperazines have been proven very effective for Phosphodiesterase-V inhibition, or PDE-5 inhibition. PDE-5 is an enzyme that binds to and digests cGMP (cyclic guanosine monophosphate). If cGMP is digested too quickly, its "relaxing" effect on penile smooth muscle tissue will be reversed, causing the erection to weaken (in many cases this will happen so rapidly; it will appear as if no erection was ever present). A PDE-5 inhibitor will block the activity of PDE-5, allowing the cGMP to remain an active part of the erection process! Only the active components: Epidithiopiperazinodione?4-Methylpiperazines have been shown to inhibit PDE-5 activity in the lichen Xanthoparmelia Scabrosa.

Xanthoparmelia Scabrosa:A Natural Substitutor of Pyrazolo pyrimidinone.

Xanthoparmelia Scabrosa X-Scabrosa Natural Pyrazolo Pyrimidinone Xanthoparmelia Lichens Utilizes Xanthoparmelia Scabrosa, a natural source of Pyrazolo pyrimidinone (a core component of leading prescription medications for impotence). This component of the Ultimate V formula serves to effectively inhibit PDE-5 activity...allowing the body to sustain an erection!

 Xanthoparmelia Scabrosa, as the natural form of Pyrazolo pyrimidinome, greatly inhibits the production of PDE-5, allowing for sustained erections.

 1).Xanthoparmelia Scabrosa- Induces smooth muscle relaxation in the penis, allowing for maximum arterial dilation and increased blood flow.

 Combined with other components (hi-lighted below), Xanthoparmelia Scabrosa offers significant support for any man experiencing difficulties with erectile dysfunction. Normally suggest Xanthoparmelia formulated with Cnidium fruit or Quebracho Extract.

 2).Quebracho Extract or Cnidium fruit?- Quebracho increases blood flow to the penis and dramatically increases libido. The Quebracho contains the highest percentage yohimbine hcl found in the world! Yet yohimbine hcl identified has almost high negative effects for people for long period uses. Cnidium fruit may be better choices more than suggested. Cnidium Monnier naturally increases nitric oxide release which powerfully increases the production of cGMP.

Xanthoparmelia Scabrosa(X-Scabrosa) as PDE-5 Inhibitor and sustained erections.

Xanthoparmelia Scabrosa X-Scabrosa Natural Pyrazolo Pyrimidinone Xanthoparmelia Lichens Once you have erectile dysfunction or have just ejaculated, the levels of cGMP in your body are extremely low as a result of the enzyme PDE-5 breaking down cGMP.

 Cyclic Guanosine Monophosphate (cGMP) is the key in obtaining and sustaining a powerful erection.cGMP relaxes the muscles around the penis, which makes it possible for the cells in the penis to take in blood, thus allows you to experience a proper erection. Your body contains an enzyme called Phosphodiesterase-V (PDE-5) which binds to and destroys cGMP.

 Benefit from Xanthoparmelia Scabrosa and Its Mechanisms:

 Finally a breakthrough in science has allowed our team of biochemists to create a product that is a truly safe and effective alternative to the extremely expensive and potentially dangerous prescription drug Viagra:

 Results in less than 1 hour.
 Xanthoparmelia scabrosa lasts up to 12 hours.
 Xanthoparmelia scabrosa improved sexual performance.
 Xanthoparmelia scabrosa increases sexual confidence.
 Xanthoparmelia scabrosa increased stamina.
 Xanthoparmelia scabrosa increased sexual drive and desire, Support healthy sexual drive and desire.
 Xanthoparmelia scabrosa increased Nitric Oxide and cGMP levels, Support healthy Nitric Oxide and cGMP levels.
 Xanthoparmelia scabrosa increased blood flow to the sexual organs.

 Xanthoparmelia scabrosa increased levels of the hormone responsible for sexual function, Support healthy levels of the hormone responsible for sexual function.

 Xanthoparmelia Scabrosa induces smooth muscle relaxation to allow for increased blood flow and maximum arterial dilation.

 Xanthoparmelia scabrosa works fast for both man and women,male and female.

 Xanthoparmelia Scabrosa, which induces smooth muscle relaxation, allowing for maximum arterial dilation and increased blood flow.

 Xanthoparmelia scabrosa extract induces smooth muscle relaxation, leading to an increase in blood flow to the penis, Make penis stay erect longer and delays the flaccid state.

 Xanthoparmelia Scabrosa greatly inhibits the production of PDE-5 allowing for sustained erections. Xanthoparmelia Scabrosa (a Natural form of Pyrazolo Pyrimidinone)- induces smooth muscle relaxation, allowing for maximum arterial dilation and increased blood flow.

 Xanthoparmelia Scabrosa, induces smooth muscle relaxation, allowing for maximum arterial dilation and increased blood flow to the penis. Xanthoparmelia Scabrosa is a natural source of Pyrazolo pyrimidinone, a core component of leading prescription medications for impotence.

 Xanthoparmelia Scabrosa extract is a natural stimulant-free pro-sexual herb developed to increase erectile quality and sexual stamina. Xanthoparmelia Scabrosa extract contains only the finest phytochemicals shown to relax penile blood vessels for better erections while increasing sexual energy and endurance.
 Xanthoparmelia Scabrosa X-Scabrosa Natural Pyrazolo Pyrimidinone Xanthoparmelia Lichens

 Longer lasting erection:

 In turn, cGMP relaxes the muscles around the penis, which makes it possible for the cells in the penis to take in blood, thus allowing you to experience a longer lasting erection. Also in your body is the enzyme Phosphodiesterase-V (PDE-5)

 Xanthoparmelia Scabrosa naturally contains the substances 4-Methylpiperazine and Pyrazolo Pyrimidin-7-1. These substances delay the work of the PDE-5 enzymes so that the penis erect longer and delays the flaccid state. Xanthoparmelia scabrosa improves the libido and guarantees that you achieve a longer lasting erection.

 Xanthoparmelia Scabrosa, a lichen said to be a natural source of a pyrimidine compound found in leading prescription medications for erectile dysfunction that inhibits the PDE-5 enzyme that binds to and breaks down cGMP, the smooth muscle relaxer produced by NO. With PDE-5 inhibited, cGMP allows the penis or clitoris to remain filled with blood. May benefit general circulation. Possible dose 50-100mg.
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X-Scabrosa and Pyrazolopyrimidinone derivatives more prominent efficacy on the treatment of impotence than sildenafil.

Xanthoparmelia Scabrosa X-Scabrosa Natural Pyrazolo Pyrimidinone Xanthoparmelia Lichens  Male erectile dysfunction is one of the most common sexual dysfunctions in men. Although erectile dysfunction can be primarily psychogenic in origin, it often accompanies chronic illnesses, such as diabetes mellitus, heart disease, hypertension, and a variety of neurological diseases. Its prevalence is strongly related to age, with an estimated prevalence of 2% at age 40 years rising to 25-30% by age of 65. Although no data are available on the prevalence of erectile dysfunction in men aged over 75, it is probably over 50%.

 Various treatment options for erectile dysfunction are available, such as counseling, hormonal therapy, self-injection or transurethral application of vasodilator agents, vacuum devices, prosthesis implantation, and venous/arterial surgery. However, these therapeutic options have several limitations such as side effects, high-cost, and low efficacy. Therefore it has called for research efforts to develop new, highly effective and simple to use treatment methods, potentially oral medication.

 Recently, sildenafil has been developed as a therapeutic agent for male erectile dysfunction by oral administration. Sildenafil is the first in a new class of drugs known as inhibiting phosphodiesterase-5 enzyme distributed specifically in corpus cavernosal tissues and induces relaxation of the corpus cavernosal smooth muscle cells, so that blood flow to the penis is enhanced, leading to an erection. Sildenafil has shown a response rate of around 80% in men with erectile dysfunction of an organic cause.

 On the other hand, U.S. Pat. No. 3,939,161 discloses that 1,3-dimethyl-1H-pyrazolopyrimidinone derivatives exhibit anticonvulsant and sedative activity, and also exhibit anti-inflammatory activity and gastric antisecretory activity; EP 201,188 discloses that 5-substituted pyrazolopyrimidinone derivatives have effects of antagonizing adenosine receptor and of inhibiting phosphodiesterase enzymes and can be used for the treatment of cardiovascular disorders such as heart failure or cardiac insufficiency; EP 463,756, EP 526,004, WO 93/6,104 and WO 93/7,149 disclose that pyrazolopyrimidinone derivatives which inhibit c-GMP phosphodiesterase more selectively than c-AMP phosphodiesterase have efficacy on cardiovascular disorders such as angina pectoris, hypertension, heart failure, atherosclerosis, chronic asthma, etc.; and WO 94/28,902, WO 96/16,644, WO 94/16,657 and WO 98/49,166 disclose that the known inhibitors of cGMP phosphodiesterase including the pyrazolopyrimidinone derivatives of the above-mentioned patents can be used for the treatment of male erectile dysfunction.

 The acid additive salts of pyrazolopyrimidinone derivatives according to the present invention have more prominent efficacy on the treatment of impotence than sildenafil, an already established therapeutic agent for impotence, based on the mechanism of inhibiting the phosphodiesterase-5 enzyme. The selectivities for phosphodiesterase-6 and phosphodiesterase-3, of the compounds according to the present invention, are much better than those of sildenafil, reducing the side effects such as visual disorders or cardiovascular disorders. Furthermore, the solubility in water at pH=2 and 5 is much more improved and the metabolism in rat liver is noticeably decreased in some of the pyrazolopyrimidinone derivatives of the present invention. Therefore the probability of better absorption and better in vivo effect can be expected when administered orally compared with sildenafil and the dose of the compound may be reduced.

 The identifier scientists of acid additive salts of pyrazolopyrimidinone derivatives have investigated to develop the improved therapeutic agent for impotence and synthesized new pyrazolo pyrimidinone derivatives which have better potency for the treatment of impotence than that of sildenafil, based on the mechanism of inhibiting the phosphodiesterase-5 enzyme. The selectivity over phosphodiesterase-6 distributed in retina and phosphodiesterase-3 distributed in heart, of the compounds of the present invention, is much more improved, to reduce the side effects. The solubility and the metabolism in the liver, which are a very important factor affecting the rate of the absorption when administered orally, of the compounds of the present invention are much more improved.
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Reference:
  • 1.Xanthoparmelia Scabrosa: Super PDE-5 Inhibitor and leader herb in sexual stimulants!

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  • Name:Xanthoparmelia Scabrosa Extract
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  • Other Names:Xanthoparmelia,Xanthoparmelia scabrosa (Taylor) Hale,Parmelia scabrosa Taylor,Xanthoparmelia hypoclystoides (Mull.Arg.)Hale,Xanthoparmelia Lichen,Huang Mei Yi.

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