Oligomeric Proanthocyanidins Introduction and Its Benefit Applications.
- Chemical Info:Oligomeric Proanthocyanidins.
- Introduction:Oligomeric Proanthocyanidins.
- Oligomeric Proanthocyanidins Discovery Story.
- Natural sources:Oligomeric Proanthocyanidins.
- Common Benefits of Oligomeric Proanthocyanidins.
- Oligomeric Proanthocyanidins Safety and Toxicity.
- Research Update:Oligomeric Proanthocyanidins.
Common Benefits of Oligomeric Proanthocyanidins.:
Boost immune system
Protection from arteriosclerosis
Enhance connective tissue health
Reduces lipid peroxidation
Boosts the effects of vitamin C
Lower cholesterol levels
Reduces inflammation and edema
Reduced cancer risk
Reduced risk of stroke and heart attack
Effective antioxidant for brain and nerve tissue
Possible arthritis reduction and relief
Helps prevent inflammation of lung tissues
Potential anti-aging benefits
Protect the blood vessels in the brain.
Reduction and repair of UV damage to cells
Reduction of muscle cramps
Potential for reduction of diabetic retinopathy
Appears to enhance and augment the antioxidant properties of vitamins E, C, and A.
Reduce histamine production, and are used in the treatment of allergies.
Help improve circulation by strengthening capillary walls. This is especially important for people with compromised circulatory systems, such as stroke victims, diabetics, arthritics, smokers, oral contraceptive users and people with general cardiovascular insufficiencies.
Inhibit enzymes that break down collagen. Proanthocyanidins help collagen repair. The breakdown of collagen is what causes our skin to lose its elasticity which in turn causes wrinkles. Proanthocyanidins help keep skin elastic, smooth and wrinkle-free. Proanthocyanidins are also taken as an oral cosmetic to help in the prevention of wrinkles.
Internal sunscreen. Inhibiting the daily effects the Sun's rays have on our skin is our best defense against the aging of our skin.
OPCs are Powerful Antioxidants
OPCs are very powerful antioxidants.Vitamin E defends against fat-soluble oxidants,and vitamin C neutralizes water-soluble ones,but OPCs are active against both types.They also help stabilize the walls of blood vessels,reduce inflammation,and generally support tissues containing collagen and elastin,proteins found in cartilage,tendons,blood vessels,skin,and muscle.
Of all the herbs and herbal supplements,OPCs are the most useful in supporting vascular health.They maintain the health of capillaries,which are the channels through which the blood delivers nutrients to individual cells and carries away waste products.Capillaries must be permeable enough to allow nutrients and oxygen to seep through them, but strong enough to prevent too much fluid from flowing out and causing edema.the beneficial effects of OPCs on capillary health result in relief of many neurological diseases and can prevent the swelling and inflammation of allergic reactions.OPCs are popular for preventing heart disease,revitalizing aging skin,and reducing a tendency to bruise easily.
Benefit of OPCs for specific health conditions include the following:
Allergies and Asthma:
OPCs stop histamine from causing swelling,inflammation,and pain in soft tissues.Their anti-oxidant action prevents the activation of enzymes known as oxygenases,which cause the release of inflammatory chemicals in response to histamine.Many allergy suffers find that OPCs eliminate all noticeable symptoms of allergy,even in the middle of the allergy season.OPCs do not inhibit the production of antibodies to allergens,and so do not interfere with desensitization treatments(allergy shots).
Alzheimer's disease and Parkinson's disease:
OPCs help to prevent blood-vessel changes in the brain that can complicate Parkinson's disease.Cell studies have shown that Pycnogenol,a patented form of pine-bark extract,can inhibit the accumulation of beta-amyloid,a peptide(protein) that accumulates in the form of plaques in the central nervous system and is toxic to nerve cells,causing a breakdown of cell membranes.These plaues are a characteristic feature of Alzheimer's disease.
Attention deficit disorder (ADD) and chronic fatigue syndrome(CFS):
Dr.Marion Sigurdson,a psychologist in Tulsa,Oklahoma,reports that OPCs extracted from a mix of grapeseeds and pine bark are as effective as methylphenidate(Ritalin) in the treatment of both adult and childhood attention deficit disorder (ADD).The manner in which OPCs affect ADD is not precisely understood,but laboratory studies suggest that OPCs help the brain to regulate its use of two excitatory neurotransmitters,dopamine and norepinephrine.This allows OPCs to act as antidepressant for people with ADD and also those with chronic fatigue syndrome without affecting nerve function in the rest of the body.
OPCs is also known to be potent antioxidants.If blood circulation to the brain of a person with ADD is impeded by allergy,high blood pressure,or muscular tension,the brain's oxygen supply is reduced.Once circulation is restored,toxic free radicals released by oxidation can flood brain tissue,destroying the linings of cells.OPCs interrupt the formation of oxygen free radicals and prevent damage to cell membrance.According to recent research,OPCs also help deliver to the brain nutrients that are helpful for people with ADD,such as zinc,manganese,selenium,and copper.OPCs also relieve neurological symptoms by acting as antihistamines.Allergic reactions can cause pain signals in the rest of the body that can overwhelm the brain,interfering with its functions of coordination and control and heightening the symptoms of ADD.By fighting allergies elsewhere,OPCs can reduce the burden on the brain and relieve symptoms of ADD.
Medical studies have demonstrated the anti-oxidant effects of OPCs.They have the ability to inhibit the initiation,promotion,and progression of cancer.Scientists at the University of Arizona found that Pycnogenol helps build resistance to cancer by as much as 40 to 50 percent by boosting the body's first line of cancer defense,the immune system's natural killer (NK) cells.
The body's overproduction of nitrous oxide (NO) can result in chronic,damaging inflammation,which is the root cause of one in three cancers.Pycnogenol has been shown to quench NO when it threatens to become a damaging free radical,and it inhibits a gene that might otherwise create enzymes that could lead to overproduction of NO.
Diabetic retinopathy and macular degeneration:
Professor Denham Harman of the University of Nebraska believes that OPCs may be the ideal medicine for macular degeneration.Proanthocyanidins concentrate in the lining of microscopic blood vessels in the eye.These delicate conduits for blood are easily blocked by cellular debris or inflammation.They are also sensitive to injury from high blood pressure or diabetes.As long as the right level of permeability is maintained,however,no damage occurs to the retina.OPCs keep the capillaries permeable enough to deliver nutrients and remove waste products.They prevent excessive permeability that would cause swelling in the nerve tissue itself.
Harman believes that the antioxidant action of proanthocyanidins also helps to protect eye tissue from damage caused by inconsistent level of oxygen.Two unpublished studies of 100 subjects found that taking 200 milligrams of grapeseed OPCs for five weeks produced improvements in night vision and glare recovery.In other studies,OPCs have been shown to relieve eyestrain in computer users,to reduce retinopathy among people with diabetes,and to improve the function of the retina in nearsighted people.
High Blood Pressure and Stroke:
People with high blood pressure have weakened capillaries that allow fluid to pass through the walls and into the tissues very easily.The tendency of capillaries to break increases the risk of hemorrhagic stroke and ruptured blood vessels.French researchers have found that grapeseed OPCs increase capillary resistance by 25 percent in people with diabetes and/or high blood pressure.German studies have found that damage from stroke is much lower in laboratory animals first treated with OPCs.
Swollen ankles,cuts and scrapes,lymphedema,nosebleed,tendinitis,and varicose veins:
When the walls of small blood vessels weaken,the fluids they transport leak out,causing swelling.OPCs strenthen capillary walls by blocking the degradation of the two proteins that give them strength and elasticity,collagen and elastin.This action stops edema and sweling. The ability of OPCs to strengthen capillary walls has been scientifically verified.a double-blind Italian study of fifty people with varicose veins found that grapeseed OPCs worked faster and longer than the most commonly used prescription drug.The OPCs relieved both the burning and tingling sensation caused by varicose veins and swelling in the lower extremities.All symptoms improved in just thirty days.A French study found that 300 miligrams of grapeseed OPCs taken daily for four weeks reduced the reported incidence of pain,nighttime leg cramps,swelling,and tingling by 50 percent.Although OPCs can relieve the pain and swelling of venous insufficiency,the cannot make visible varicose veins disappear.But regular use might help prevent new ones from developing.
There is some evidence that OPCs can be useful for swelling following an injury or surgery.A double-blind controlled study found that postoperative breast cancer patients who took 600 milligrams of OPCs daily for six months experienced a sgnificant reduction in swelling,pain,and sensations known as paresthesias.Another double blind controlled study found that OPCs improved the rate at which swelling disappeared following sports injuries.
- 1.Oligomeric Proanthocyanidins,OPCs:Introduction and Its Benefit Applications.
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